1522004-68-7

Upstream product

• 1615686-87-7 (E)-7-((2S,6S)-6-isopropoxy-4-methyl-3,6-dihydro-2H-pyran-2-yl)-6-methyl-2-methylenehept-6-enal 
• 1615686-86-6 (E)-7-((2S,6S)-6-isopropoxy-4-methyl-3,6-dihydro-2H-pyran-2-yl)-6-methylhept-6-enal 
• 1615686-85-5 (E)-7-((2S,6S)-6-isopropoxy-4-methyl-3,6-dihydro-2H-pyran-2-yl)-6-methylhept-6-en-1-ol 
• 1615686-84-4 tert-butyl(((E)-7-((2S,6S)-6-isopropoxy-4-methyl-3,6-dihydro-2H-pyran-2-yl)-6-methylhept-6-en-1-yl)oxy)dimethylsilane 
• 1615686-82-2 tributyl((E)-1-((2S,6S)-6-isopropoxy-4-methyl-3,6-dihydro-2H-pyran-2-yl)prop-1-en-2-yl)stannane 
• 1615686-83-3 (2S,6S)-2-((E)-2-iodoprop-1-en-1-yl)-6-isopropoxy-4-methyl-3,6-dihydro-2H-pyran 

Relevant academic research and scientific papers

Total synthesis of aphadilactones A-D

The first total synthesis of aphadilactones A-D, diastereomeric natural products recently isolated from the Meliaceae plant Aphanamixis grandifolia by Yue and co-workers, which possess an unprecedented carbon skeleton, has been achieved. The synthesis features a catalytic asymmetric hetero-Diels-Alder reaction to form the dihydropyran ring, concurrent installation of the lactone and furan moieties via a tandem acid-catalyzed acetal cleavage, oxidation, and cyclization process, and an intermolecular Diels-Alder reaction to forge the target products.