152213-40-6

Basic information

• Product Name: 5-AMINO-2-INDOLECARBOXYLIC ACID
• Synonyms: 5-AMINO-2-INDOLE CARBOXYLIC ACID;5-amino-1H-indole-2-carboxylic acid
• CAS NO: 152213-40-6
• Molecular Formula: C₉H₈N₂O₂
• Molecular Weight: 176.17
• Mol File: 152213-40-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 518.715 °C at 760 mmHg
• Flash Point: 267.51 °C
• Appearance: /
• Density: 1.51 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.796
• Storage Temp.: 2-8°C(protect from light)
• PKA: 4.01±0.30(Predicted)
• CAS DataBase Reference: 5-AMINO-2-INDOLECARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 5-AMINO-2-INDOLECARBOXYLIC ACID(152213-40-6)
• EPA Substance Registry System: 5-AMINO-2-INDOLECARBOXYLIC ACID(152213-40-6)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 152213-40-6(Hazardous Substances Data)

Usage

General Description

5-Amino-2-indolecarboxylic acid, also known as indole-3-carboxylic acid, is a chemical compound with a molecular formula C10H9N2O2. It is an amino acid derivative and a tryptophan metabolite found in plants and microorganisms. 5-Amino-2-indolecarboxylic acid has been studied for its potential use in biomedical applications, particularly for its anti-inflammatory, antioxidant, and anticancer properties. It has also been investigated for its role in plant growth and development, as well as its potential as a precursor for the synthesis of biologically active molecules. 5-Amino-2-indolecarboxylic acid has shown promising potential in various research fields and continues to be a subject of interest for further studies.

InChI:InChI=1/C9H8N2O2/c10-6-1-2-7-5(3-6)4-8(11-7)9(12)13/h1-4,11H,10H2,(H,12,13)

Upstream product

• 16730-20-4 5-nitro-1H-indole-2-carboxylic acid 
• 481659-88-5 1-ethyl-5-nitro-1H-indole-2-carboxylic acid ethyl ester 
• 409315-76-0 5-isocyanato-indole-2-carboxylic acid ethyl ester 
• 138731-14-3 1H-indole-2,5-dicarboxylic acid 2-ethyl ester 
• 16732-57-3 5-nitro-indole-2-carboxylic acid ethyl ester 
• 71086-99-2 ethyl 5-amino-1H-indole-2-carboxylate 

Downstream Products

• 138730-81-1 5-[(tert-Butyloxycarbonyl)amino]indole-2-carboxylic Acid 
• 152213-39-3 5-[(3-phenyldithio)propionylamino]-indole-2-carboxylic acid 
• 136817-55-5 delavirdine 

Relevant articles and documents

Sequence-specific alkylation of double-strand human telomere repeat sequence by pyrrole-imidazole polyamides with indole linkers

We designed and synthesized pyrrole (Py)-imidazole (Im) hairpin polyamide 1-(chloromethyl)-5-hydroxy-1,2-dihydro-3H-benz[e]indole (seco-CBI) conjugates 1 and 2, which target both strands of -the double-stranded region of the human telomere repeat sequences, 5′-d(TTAGGG)n-3′/5′- d(CCCTAA)n-3′. High-resolution denaturing polyacrylamide gel electrophoresis demonstrated that conjugates 1 and 2 alkylated DNA at the 3′ A of 5′-ACCCTA-3′ and 5′-AGGGTTA-3′, respectively. Cytotoxicities of conjugates 1 and 2 were evaluated using 39 human cancer cell lines; averages of log IC50 values for conjugates 1 and 2 were -6.96 (110 nM) and -7.24 (57.5 nM), respectively. Conjugates 1 and 2 have potential as antitumor drugs capable of targeting telomere repeat sequence.

SECO-CYCLOPROPAPYRROLOINDOLE COMPOUNDS, ANTIBODY-DRUG CONJUGATES THEREOF, AND METHODS OF MAKING AND USE

seco-Cyclopropapyrroloindole compounds of formula (I) where Hal, R1, R2, and R3 are as defined in the application, are potent anti-cancer agents that can be used in antibody-drug conjugates.

Phosphate mimics and methods of treatment using phosphatase inhibitors

The invention relates to trifluoromethyl sulfonyl and trifluoromethyl sulfonamido compounds and the physiologically acceptable salts and the prodrugs thereof. These compounds are expected to modulate the activity of protein tyrosine enzymes which are related to cellular signal transduction, in particular, protein tyrosine phosphatase, and therefore are expected to be useful in the prevention and treatment of disorders associated with abnormal protein tyrosine enzyme related cellular signal transduction such as cancer, diabetes, immuno-modulation, neurologic degenerative diseases, osteoporosis and infectious diseases. The invention also relates to the use of compounds containing fluoromethyl sulfonyl groups as phosphate mimics. These mimics may be used to inhibit, regulate or modulate the activity of a phosphate binding protein in a cell.