152213-61-1

Basic information

• Product Name: 6-Bromoindole-3-acetonitrile
• Synonyms: 6-Bromoindole-3-acetonitrile;2-(6-bromo-1H-indol-3-yl)acetonitrile
• CAS NO: 152213-61-1
• Molecular Formula: C10H7BrN2
• Molecular Weight: 235.07998
• Mol File: 152213-61-1.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 427.5±30.0 °C(Predicted)
• Appearance: /
• Density: 1.629±0.06 g/cm3(Predicted)
• PKA: 15.39±0.30(Predicted)
• CAS DataBase Reference: 6-Bromoindole-3-acetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Bromoindole-3-acetonitrile(152213-61-1)
• EPA Substance Registry System: 6-Bromoindole-3-acetonitrile(152213-61-1)

Safety Data

• Hazardous Substances Data: 152213-61-1(Hazardous Substances Data)

Usage

General Description

6-Bromoindole-3-acetonitrile is a chemical compound with the molecular formula C10H7BrN2. It is a derivative of indole and contains a bromine atom and an acetonitrile functional group. 6-Bromoindole-3-acetonitrile is commonly used as an intermediate in the synthesis of pharmaceutical products and agrochemicals. Its unique structure and properties make it valuable for the development of new drugs and other biologically active compounds. 6-Bromoindole-3-acetonitrile has potential applications in the pharmaceutical and agrochemical industries due to its ability to modulate biological activity and its versatility in chemical synthesis. However, as with all chemical compounds, proper handling and storage procedures should be followed to ensure safety and prevent adverse reactions.

Upstream product

• 17826-04-9 6-bromo-1H-indole-3-carbaldehyde 
• 773837-37-9 sodium cyanide 
• 52415-29-9 6-bromo-1H-indole 
• 74-88-4 methyl iodide 
• 59609-63-1 6-Bromogramine 
• 830-93-3 N-[(5-bromo-1H-indol-3-yl)methyl]-N,N-dimethylamine 
• 10075-50-0 5-bromo-1H-indole 

Downstream Products

• 152213-66-6 2-(6-bromo-1H-indol-3-yl)acetic acid 
• 152213-63-3 (6-bromo-1H-indol-3-yl)acetic acid methyl ester 

Relevant articles and documents

Asymmetric Dearomatizing Fluoroamidation of Indole Derivatives with Dianionic Phase-Transfer Catalyst

Asymmetric dearomatizing fluorocyclization of indole derivatives was investigated using a dicarboxylate phase-transfer catalyst. This reaction proceeds under mild reaction conditions to provide fluoropyrroloindoline derivatives in a highly enantioselective manner. Various substitution patterns on the indole ring are well tolerated. To facilitate the reaction and ensure reproducibility, the addition of water is essential, and its possible role is discussed.

SELECTIVE ANTI-CANCER COMPOUNDS

A compound of formula I, wherein the compound of formula I has the structure: wherein R1 to R5, Y, L, Z and X1 to X7 have meanings given in the description, said compounds having utility in the treatment of hyperproliferative disease.

New synthetic approach to paullones and characterization of their SIRT1 inhibitory activity

A series of 7,12-dihydroindolo[3,2-d][1]benzazepine-6(5H)-ones (paullones) substituted at C9/C10 (Br) and C2 (Me, CF3, CO2Me) have been synthesized by a one-pot Suzuki-Miyaura cross-coupling of an o-aminoarylboronic acid and methyl 2-iodoindoleacetate followed by intramolecular amide formation. Other approaches to the paullone scaffold based on Pd-catalyzed C-H activation were unsuccessful. In vitro enzymatic assay with recombinant human SIRT-1 indicated a strong inhibitory profile for the series, in particular the analogue with a methoxycarbonyl group at C2 and a bromine at C9. These compounds are, in general, inducers of granulocyte differentiation of the U937 acute leukemia cell line and cause a marked increase in pre-G1 of the cell cycle.