152252-72-7Relevant academic research and scientific papers
Generation of Radical Cations from Enamines and Their Addition to Unactivated Olefins
Cossy, Janine,Bouzide, Abderrahim
, p. 1218 - 1219 (1993)
Oxidation of unsaturated enamines by metallic salts produced radical cations which added intramolecularly to unactivated olefins, producing cyclized products in a highly efficient manner.
Metallic salt promoted radical cyclization of β-keto carboxamides and their corresponding β-enamino carboxamides
Cossy,Bouzide,Leblanc
, p. 7257 - 7265 (2007/10/03)
Substituted lactams and spirolactams were obtained by Mn(III)-induced radical cyclization of unsaturated β-keto carboxamides. Treatment of the corresponding tertiary enamines under similar reaction conditions and in the presence of K2CO3 afforded the same cyclized products but with inversion of diastereoselectivity. The oxidation of optically pure secondary enamines leads to diastereomeric spirolactams in an approximately 3:1 ratio.
