15228-74-7Relevant academic research and scientific papers
A concise asymmetric total synthesis of (+)-fawcettimine
Zeng, Xin,Jia, Zhuqing,Qiu, Fayang G.
, (2020/09/16)
A straightforward and stereocontrolled total synthesis of (+)-fawcettimine was accomplished from the known (R)-5-methyl-2-cyclohexen-one in 11 steps. The synthesis features a palladium mediated cycloalkenylation of a silyl enol ether for assembling the 6/
Enantioselective divergent total syntheses of fawcettimine-type Lycopodium alkaloids
Zeng, Chen,Zhao, Jingyun,Zhao, Gang
, p. 64 - 69 (2015/02/02)
Enantioselective divergent total syntheses of (+)-fawcettimine, (+)-fawcettidine, (+)-lycoflexine, (+)-lycoposerramine Q, (-)-Huperzine Q and (+)-N-oxyhuperzine Q have been described from a common precursor. The syntheses feature a vinylogous Rubottom oxidation and several biomimetic transformations.
Total synthesis of (+)-fawcettimine
Linghu, Xin,Kennedy-Smith, Joshua J.,Toste, F. Dean
, p. 7671 - 7673 (2008/09/18)
An effective combination: With the first asymmetric total synthesis of fawcettimine (1) it has been shown that the use of organocatalytic annulation and gold(I)-catalyzed cyclization reactions provides an effective combination for the synthesis of complex molecules. The absolute configuration of 1 was established through an X-ray structure analysis of its hydrobromide. (Figure Presented).
