1522975-22-9Relevant academic research and scientific papers
A small molecule for controlled generation of reactive oxygen species (ROS)
Dharmaraja, Allimuthu T.,Chakrapani, Harinath
supporting information, p. 398 - 401 (2014/04/03)
Due to the short half-life of reactive oxygen species (ROS) such as a superoxide radical, controlled and localized generation of ROS is challenging. Here, we report a rationally designed small-molecule 1c that generates ROS only when triggered by a bacterial enzyme. We provide evidence for 1c predictably enhancing the intracellular superoxide radical in a model bacterium. Spatiotemporal control over ROS generation offered by 1c should help better understand stress responses in bacteria to increased ROS.
