152298-51-6

Basic information

• Product Name: 4-Amino-3-(3,4-dichlorophenyl)-1-butanol
• Synonyms: 2-(3,4-Dichlorophenyl)-4-hydroxybutylamine;4-Amino-3-(3,4-dichlorophenyl)-1-butanol;DICHLOROPHENYL AMINO ALCOHOL
• CAS NO: 152298-51-6
• Molecular Formula: C₁₀H₁₃Cl₂NO
• Molecular Weight: 234.12
• Mol File: 152298-51-6.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 359.377 °C at 760 mmHg
• Flash Point: 171.146 °C
• Appearance: /
• Density: 1.292
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.576
• PKA: 14.88±0.10(Predicted)
• CAS DataBase Reference: 4-Amino-3-(3,4-dichlorophenyl)-1-butanol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Amino-3-(3,4-dichlorophenyl)-1-butanol(152298-51-6)
• EPA Substance Registry System: 4-Amino-3-(3,4-dichlorophenyl)-1-butanol(152298-51-6)

Safety Data

• Hazardous Substances Data: 152298-51-6(Hazardous Substances Data)

Usage

General Description

4-Amino-3-(3,4-dichlorophenyl)-1-butanol is a chemical compound that belongs to the family of phenylbutanols. It is a white crystalline powder with a molecular formula of C10H13Cl2NO and a molecular weight of 239.12 g/mol. 4-Amino-3-(3,4-dichlorophenyl)-1-butanol is used in the synthesis of pharmaceutical agents and in the preparation of organic intermediates. It has also been studied for its potential pharmacological effects, particularly its neuroprotective and analgesic properties. Additionally, it has been investigated for its role as an antioxidant and anti-inflammatory agent. Therefore, 4-Amino-3-(3,4-dichlorophenyl)-1-butanol is a versatile compound with potential applications in the pharmaceutical and medical fields.

InChI:InChI=1/C10H13Cl2NO/c11-9-2-1-7(5-10(9)12)8(6-13)3-4-14/h1-2,5,8,14H,3-4,6,13H2

Upstream product

• 101466-77-7 4-nitro-3-(3,4-dichlorophenyl)butanoic acid methyl ester 
• 60-29-7 diethyl ether 
• 7757-82-6 sodium sulfate 
• 176044-72-7 3-cyano-3-(3,4-dichlorophenyl)propionic acid 
• 135936-08-2 1-Amino-2-(3,4-dichlorophenyl)-4-(tetrahydropyran-2-yloxy)butane 
• 3218-49-3 3,4-dichloro-benzeneacetonitrile 
• 135936-16-2 α-[2-(Tetrahydropyran-2-yloxy)ethyl]-3,4-dichlorophenyl-acetonitrile 

Downstream Products

• 135936-08-2 1-Amino-2-(3,4-dichlorophenyl)-4-(tetrahydropyran-2-yloxy)butane 
• 173942-48-8 C₃₀H₃₁Cl₂N₃O₄ 
• 173943-90-3 (+/-)-1'-<3-(3,4-dichlorophenyl)-4-methylaminobutyl>spiro 

Relevant articles and documents

4-Amino-2-(aryl)-butylbenzamides and their conformationally constrained analogues. Potent antagonists of the human neurokinin-2 (NK2) receptor

A library, evaluating a range of piperazines, piperidines and acyclic amines, as replacements for the 4-hydroxy-4-phenylpiperidine moiety in lead (1b) was prepared. These efforts identified the 4-((N)-benzimidazolone)piperidine analogue (2a) which was further optimised using classical single-compound synthesis to yield the 3-((N)-morpholino)azetidine (2j). Conformationally constrained analogues of (2j), generally offered no potency advantage in this particular series.

PIPERIDINE DERIVATIVES, PROCESS FOR OBTAINING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Piperidine derivatives, process for obtaining them and pharmaceutical compositions containing them, of formula STR1 used as neurokinin receptor antagonists, which are, in particular, useful for the treatment of all substance P-and neurokinin-dependent pathologies.

Aryl substituted heterocycles

The present invention concerns the novel use of aryl substituted heterocycles of formula I, set out below, which antagonize the pharmacological actions of one of ent endogenous neuropeptide tachykinins an the neurokinin 2 (NK2) receptor making them useful whenever such antagonism is desired, such as in the treatment of asthma and related conditions. The invention also provides pharmaceutical compositions containing the aryl substituted heterocycles for use in such treatment. Certain novel aryl substituted heterocycles of formula I and novel intermediates for their manufacture are also provided. STR1