152298-99-2Relevant academic research and scientific papers
2-Dibenzylaminobutane-1,4-diol: An Effective Chiral Building Block for the Synthesis of 1,2-Amino Alcohols
Gmeiner, Peter,Kaertner, Annerose
, p. 83 - 87 (2007/10/02)
Regioselective activation and protection of the chiral building block 1, readly available from L-aspartic acid, leads to the key intermediate 8.Employing classical nucleophiles, heterocyclic anions or organocuprates, 8 could be transformed into the displa
PRACTICAL EPC SYNTHESIS OF 1,2- AND 1,3-AMINO ALCOHOLS
Gmeiner, Peter,Kaertner, Annerose,Junge, Dagmar
, p. 4325 - 4326 (2007/10/02)
An efficient synthesis of enantiomerically pure 1,2- and 1,3-amino alcohols (4,10) through the key intermediates 2 and 8a,b, obtained from L-aspartic acid, is reported.Using 4d as an example it is shown that the products can serve as percursors for unusual amino aldehydes and nonproteinogenic amino acids.
