152300-59-9

Basic information

• Product Name: ethyl 4-aminothiazole-5-carboxylate
• Synonyms: ethyl 4-aminothiazole-5-carboxylate;5-Thiazolecarboxylic acid, 4-aMino-, ethyl ester;ethyl 4-aMinothiazole-5-carboxylateethyl ester
• CAS NO: 152300-59-9
• Molecular Formula: C₆H₈N₂O₂S
• Molecular Weight: 172
• Mol File: 152300-59-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 300.7±22.0 °C(Predicted)
• Appearance: /
• Density: 1.336±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 1.39±0.10(Predicted)
• CAS DataBase Reference: ethyl 4-aminothiazole-5-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 4-aminothiazole-5-carboxylate(152300-59-9)
• EPA Substance Registry System: ethyl 4-aminothiazole-5-carboxylate(152300-59-9)

Safety Data

• Hazardous Substances Data: 152300-59-9(Hazardous Substances Data)

Usage

General Description

Ethyl 4-Aminothiazole-5-carboxylate is a chemical compound with the molecular formula C7H8N2O2S. It is a derivative of aminothiazole and is commonly used in pharmaceutical research and manufacturing as a precursor for the synthesis of various drugs and drug candidates. It is a white to off-white crystalline powder that is slightly soluble in water and ethanol. Ethyl 4-Aminothiazole-5-carboxylate has potential biological activities and has been studied for its antifungal and antibacterial properties. It is important to handle ethyl 4-Aminothiazole-5-carboxylate with care and in a controlled environment due to its potential health hazards and reactivity.

Upstream product

• 39736-29-3 ethyl 4-amino-2-(methylthio)thiazol-5-carboxylate 

Downstream Products

• 1043931-24-3 C₁₃H₁₁FN₂O₃S 

Relevant articles and documents

NOVEL TETRAZOLES

This invention relates to tetrazoles and their use as inhibitors of TRPA1 activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of fibrotic diseases, inflammatory and auto-immune

Synthetic method of 4-aminothiazole-5-carboxylic acid ethyl ester

The invention belongs to the technical field of medical intermediates, and relates to a synthetic method of 4-aminothiazole-5-carboxylic acid ethyl ester. The synthetic method comprises the steps that4-amino-2-(methylthio)thiazol-5-carboxylic acid ethyl ester is dissolved in anhydrous ethanol, concentrated hydrochloric acid is added, zinc powder is added in batches under agitation, and a refluxing reaction is conducted for 4 hours to obtain a neutralization solution; the neutralization solution is filtered, a filter cake is washed with ethanol for 2-3 times, filter liquor is combined, vacuumconcentration is conducted, and a concentrated solution is obtained; dichloromethane and water are added into the concentrated solution and agitated to separate an organic phase; and the organic phaseis washed by a saturated sodium chloride solution, and is dried and concentrated by anhydrous sodium sulfate, and isopropanol is used for crystallizing to obtain the 4-aminothiazole-5-carboxylic acidethyl ester. According to the synthetic method, a novel method for removing methylthio group from an aromatic ring, the cost of raw materials is low, the yield is high, and the synthetic method is suitable for scale-up production.