152330-49-9Relevant academic research and scientific papers
SYNTHESIS OF 2,3-FUSED QUINOLINES FROM 3-SUBSTITUTED QUINOLINE 1-OXIDES. PART III. INTRAMOLECULAR CYCLIZATION OF QUINOLINE 1-OXIDES BEARING ACTIVE METHYLENE GROUPS AT THE 3-POSITION IN THE PRESENCE OF ACETIC ANHYDRIDE
Miura, Yutaka,Fujimura, Yasuo,Takaku, Sakae,Hamana, Masamoto
, p. 693 - 699 (2007/10/02)
3-N-Alkylcyanoacetamidoquinoline 1-oxides (3a and 3c) react with Ac2O at room temperature in chloroform to afford 1-alkyl-3-cyano-4H-pyrroloquinolin-2-ones (4a and 4c).The cyclization of 3-N-alkylethoxycarbonylacetamidoquinoline 1-oxides (3b and 3d) occurs upon heating with Ac2O at 60 deg C. 3-(3,3-Dicyanopropoxy)quinoline 1-oxide (5) also cyclizes to the pyranoquinoline (6) when treated with Ac2O at room temperature in chloroform-DMF.
