152340-67-5

Basic information

• Product Name: calythropsin
• Synonyms: calythropsin
• CAS NO: 152340-67-5
• Molecular Formula: C₁₆H₁₄O₅
• Molecular Weight: 286.27936
• Mol File: 152340-67-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 555.2°Cat760mmHg
• Flash Point: 210.4°C
• Appearance: /
• Density: 1.369g/cm³
• Vapor Pressure: 6.21E-13mmHg at 25°C
• Refractive Index: 1.684
• CAS DataBase Reference: calythropsin(CAS DataBase Reference)
• NIST Chemistry Reference: calythropsin(152340-67-5)
• EPA Substance Registry System: calythropsin(152340-67-5)

Safety Data

• Hazardous Substances Data: 152340-67-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C16H14O5/c1-21-11-4-5-12(15(19)9-11)13(17)6-2-10-3-7-14(18)16(20)8-10/h2-9,18-20H,1H3/b6-2+

Upstream product

• 64000-54-0 3,4-diisopropyloxybenzaldehyde 
• 139-85-5 3,4-dihydroxybenzaldehyde 
• 552-41-0 1-(2-hydroxy-4-methoxyphenyl)ethanone 
• 61854-89-5 3,4-di-[(tetrahydro-2H-pyran-2-yl)oxy]-benzaldehyde 

Downstream Products

• 94428-61-2 2-(3,4-dihydroxyphenyl)-3-hydroxy-7-methoxy-4H-chromen-4-one 

Relevant articles and documents

Reactivity assessment of chalcones by a kinetic thiol assay

The electrophilic nature of chalcones (1,3-diphenylprop-2-en-1-ones) and many other α,β-unsaturated carbonyl compounds is crucial for their biological activity, which is often based on thiol-mediated regulation processes. To better predict their biological activity a simple screening assay for the assessment of the second-order rate constants (k2) in thia-Michael additions was developed. Hence, a clear structure-activity relationship of 16 differentially decorated hydroxy-alkoxychalcones upon addition of cysteamine could be established. Moreover, amongst other naturally occurring α,β-unsaturated carbonyl compounds k2 values for curcumin and cinnamaldehyde were gained while cinnamic acids or esters gave no or very slow reactions.

3,4-Dihydroxychalcones as potent 5-lipoxygenase and cyclooxygenase inhibitors

A novel series of 3,4-dihydroxychalcones was synthesized to evaluate their effects against 5-lipoxygenase and cyclooxygenase. Almost all compounds exhibited potent inhibitory effects on 5-lipoxygenase with antioxidative effects, and some also inhibited cyclooxygenase. The 2',5'-disubstituted 3,4- dihydroxychalcones with hydroxy or alkoxy groups exhibited optimal inhibition of cyclooxygenase. We found that 2',5'-dimethoxy-3,4-dihydroxychalcone (37; HX-0836) inhibited cyclooxygenase to the same degree as flufenamic acid and 5-lipoxygenase, more than quercetin. Finally, these active inhibitors of 5- lipoxygenase inhibited arachidonic acid-induced mouse ear edema more than phenidone.