152342-26-2

Basic information

• Product Name: (2-BENZYL-1H-BENZIMIDAZOL-1-YL)ACETIC ACID
• Synonyms: CHEMBRDG-BB 6722348;(2-BENZYL-1H-BENZIMIDAZOL-1-YL)ACETIC ACID;(2-BENZYL-BENZOIMIDAZOL-1-YL)-ACETIC ACID;ALINDA 14480;(2-benzyl-1H-benzimidazol-1-yl)acetic acid(SALTDATA: FREE)
• CAS NO: 152342-26-2
• Molecular Formula: C₁₆H₁₄N₂O₂
• Molecular Weight: 266.29
• Mol File: 152342-26-2.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 531.4°C at 760 mmHg
• Flash Point: 275.2°C
• Appearance: /
• Density: 1.24g/cm³
• Vapor Pressure: 4.01E-12mmHg at 25°C
• Refractive Index: 1.639
• CAS DataBase Reference: (2-BENZYL-1H-BENZIMIDAZOL-1-YL)ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (2-BENZYL-1H-BENZIMIDAZOL-1-YL)ACETIC ACID(152342-26-2)
• EPA Substance Registry System: (2-BENZYL-1H-BENZIMIDAZOL-1-YL)ACETIC ACID(152342-26-2)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 152342-26-2(Hazardous Substances Data)

Usage

General Description

(2-Benzyl-1H-benzimidazol-1-yl)acetic acid is a chemical compound that belongs to the class of benzimidazoles, which are heterocyclic compounds. It is a synthetic molecule with a benzimidazole core that is substituted with a benzyl group and an acetic acid group. (2-BENZYL-1H-BENZIMIDAZOL-1-YL)ACETIC ACID may have potential applications in pharmaceuticals and drug development due to its structural features and potential biological activities. Additionally, it may also be used in research and development as a building block for the synthesis of other bioactive compounds. Overall, (2-Benzyl-1H-benzimidazol-1-yl)acetic acid is a versatile chemical that offers a wide range of potential uses in various fields.

InChI:InChI=1/C16H14N2O2/c19-16(20)11-18-14-9-5-4-8-13(14)17-15(18)10-12-6-2-1-3-7-12/h1-9H,10-11H2,(H,19,20)

Upstream product

• 105949-50-6 ethyl 2-(2-benzyl-1H-benzimidazol-1-yl)acetate 
• 621-72-7 2-benzylbenzimidazole 
• 667408-26-6 methyl 2-(2-benzyl-1H-benzo[d]imidazol-1-yl)acetate 
• 329937-74-8 N-(2-iodophenyl)-2-phenylacetamide 
• 615-43-0 2-iodophenylamine 
• 103-80-0 phenylacetyl chloride 

Downstream Products

• 1602747-31-8 2-(2-benzyl-1H-benzo[d]imidazol-1-yl)-N-(3,5-di-tert-butylphenyl)acetamide 
• 1602747-25-0 2-(2-benzyl-1H-benzo[d]imidazol-1-yl)-N-(5-isopropyl-2-methylphenyl)acetamide 
• 1602747-32-9 2-(2-benzyl-1H-benzo[d]imidazol-1-yl)-N-(2-(tert-butyl)-6-methylphenyl)acetamide 
• 1602747-27-2 2-(2-benzyl-1H-benzo[d]imidazol-1-yl)-N-(5-(biphenyl-4-yloxy)-2-fluorophenyl)acetamide 

Relevant articles and documents

Discovery of benzimidazole derivatives as modulators of mitochondrial function: A potential treatment for Alzheimer's disease

In this study, we designed a library of compounds based on the structures of well-known ligands of the 18 kDa translocator protein (TSPO), one of the putative components of the mPTP. We performed diverse mitochondrial functional assays to assess their ability to restore cells from Aβ-induced toxicity in vitro and in vivo. Among tested compounds, compound 25 effectively improved cognitive function in animal models of AD. Given the excellent in vitro and in vivo activity and a favorable pharmacokinetic profile of compound 25, we believe that it can serve as a promising lead compound for a potential treatment option for AD.

Research In The Imidazole Series. 93. Synthesis Of Derivatives Of Benzimidazolyl-1-Acetic Acid

A simple method has been developed for obtaining esters of benzimidazolyl-1-acetic acid and its 2-alkyl (or aralkyl) derivatives, by reaction of benzimidazoles with esters of chloroacetic or bromoacetic acid in DMF in the presence of anhydrous potassium c