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152368-04-2

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152368-04-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 152368-04-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,2,3,6 and 8 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 152368-04:
(8*1)+(7*5)+(6*2)+(5*3)+(4*6)+(3*8)+(2*0)+(1*4)=122
122 % 10 = 2
So 152368-04-2 is a valid CAS Registry Number.

152368-04-2Downstream Products

152368-04-2Relevant articles and documents

Synthesis, Antibacterial Evaluation, and QSAR of Caffeic Acid Derivatives

Araújo, Marianna O.,Freire Pessoa, Hilzeth L.,Lira, Andressa B.,Castillo, Yunierkis P.,De Sousa, Dami?o P.

, (2019/03/07)

The present study evaluates the antibacterial effects of a set of 16 synthesized caffeic acid ester derivatives against strains of Staphylococcus aureus and Escherichia coli, as well as discusses their structure-activity relationship (SAR). The antibacterial assays were performed using microdilution techniques in 96-well microplates to determine minimal inhibitory concentration (MIC). The results revealed that five of the compounds present strong to optimum antibacterial effect. Of the sixteen ester derivatives evaluated, the products with alkyl side chains, as propyl caffeate (3), butyl caffeate (6), and pentyl caffeate (7), presented the best antibacterial activity with MIC values of around 0.20 μM against Escherichia coli and only butyl caffeate (6) showing the same MIC against Staphylococcus aureus. For products with aryl substituents, the best MIC results against the tested strain of Escherichia coli were 0.23 μM for (di-(4-chlorobenzyl)) caffeate (13) and 0.29 μM for diphenylmethyl caffeate (10) and all were less active against the Staphylococcus aureus strain. Preliminary quantitative structure-activity relationship (QSAR) analyses confirmed that certain structural characteristics, such as a median linear carbon chain and the presence of electron withdrawal substituents at the para position of the aromatic ring, help potentiate antibacterial activity.

Design and synthesis of novel aspirin-caffeic acid ester hybrids for cardioprotection with reduced risk of hemorrhagic stroke

Shi, Zhi-Hao,Li, Nian-Guang,Tang, Yu-Ping,Shi, Qian-Ping,Zhang, Wei,Zhang, Peng-Xuan,Dong, Ze-Xi,Li, Wei,Duan, Jin-Ao

, p. 1342 - 1346 (2016/06/13)

A series of novel aspirin-caffeic acid ester hybrids for cardioprotection with reduced risk of hemorrhagic stroke were designed and synthesized by coupling aspirin and caffeic acid esters inspired by NCX-4016. The synthesized compounds were evaluated for

Antihypertensive effect of caffeic acid and its analogs through dual renin-angiotensin-aldosterone system inhibition

Bhullar, Khushwant S.,Lassalle-Claux, Grégoire,Touaibia, Mohamed,Vasantha Rupasinghe

, p. 125 - 132 (2014/04/17)

Hypertension is a crucial risk factor for cardiovascular diseases and contributes to one third of global mortality. In addition to conventional antihypertensive drugs such as captopril, naturally occurring phytochemicals and their analogs are used for red

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