152397-85-8

Basic information

• Product Name: methyl 2,2-dichloro-3-(4-methoxyphenyl)-3-oxopropionate
• Synonyms: methyl 2,2-dichloro-3-(4-methoxyphenyl)-3-oxopropionate
• CAS NO: 152397-85-8
• Molecular Weight: 277.104
• Mol File: 152397-85-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: methyl 2,2-dichloro-3-(4-methoxyphenyl)-3-oxopropionate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2,2-dichloro-3-(4-methoxyphenyl)-3-oxopropionate(152397-85-8)
• EPA Substance Registry System: methyl 2,2-dichloro-3-(4-methoxyphenyl)-3-oxopropionate(152397-85-8)

Safety Data

• Hazardous Substances Data: 152397-85-8(Hazardous Substances Data)

Upstream product

• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 78437-40-8 methyl 2-chloro-3-(4-methoxyphenyl)-3-oxopropionate 
• 22027-50-5 methyl 3-(4-methoxybenzoyl)acetate 

Downstream Products

• 152397-94-9 (3S)-methyl 2,2-dichloro-3-hydroxy-3-(4-methoxyphenyl)propionate 

Relevant articles and documents

Geminal Dichlorination of Phenyliodonium Ylides of β-Dicarbonyl Compounds through Double Ligand Transfer from (Dichloroiodo)benzene

Pre-formed phenyliodonium ylides of cyclic and acyclic β-diketones, β-keto esters and β-diesters were reacted with (dichloroiodo)benzene, resulting in transfer of both chloride ligands onto the ylidic carbon. These two hypervalent iodine(III) compounds exhibit high reactivity towards each other under mild reaction conditions and typically afford the gem-dichloride products in good yield. Upon comparison of these chlorination reactions with those of the analogous diazocarbonyl compounds, reactions of iodonium ylides were unilaterally faster, and often gave the products in higher yield.

Asymmetric reduction of aromatic ketones. II. An enantioselective synthesis of methyl (2R,3S)-3-(4-methoxyphenyl)glycidate

Asymmetric reduction of some 3-keto esters (6, 8, and 11) to 3-hydroxy esters (7, 9, and 12) with various chiral reducing agents was investigated. The products (9 and 12) were converted to methyl (2R,3S)-3-(4-methoxyphenyl)glycidate (2R,3S-3), a key intermediate in the practical enantioselective synthesis of diltiazem (1).