15240-91-2Relevant academic research and scientific papers
A two-step, formal [4 + 2] approach toward piperidin-4-ones via au catalysis
Cui, Li,Peng, Yu,Zhang, Liming
supporting information; experimental part, p. 8394 - 8395 (2009/10/23)
(Chemical Equation Presented) An efficient, formal [4 + 2] synthesis of synthetically valuable piperidin-4-ones from secondary amines in two steps has been achieved via a key gold catalysis without the purification of tertiary amine intermediates. This reaction is selective toward the less-substituted alkyl group and shows moderate to excellent diastereoselectivities. Its synthetic potential in alkaloid synthesis is demonstratedin a highly diastereoselective synthesis of (±)-cermizine C.
