152401-13-3

Upstream product

• 91-10-1 1,3-dimethoxy-2-hydroxy-benzene 
• 70654-71-6 4-bromo-2,6-dimethoxyphenol 
• 18162-48-6 tert-butyldimethylsilyl chloride 

Downstream Products

• 1055031-30-5 Acetic acid 4-[(2R,3S,4S)-3-benzyloxy-2,4-bis-benzyloxymethoxy-5-(tert-butyl-diphenyl-silanyloxy)-pentyl]-2,6-dimethoxy-phenyl ester 
• 152401-21-3 (4R,5S,6R)-5-Benzyloxy-4,6-bis-benzyloxymethoxy-7-(4-hydroxy-3,5-dimethoxy-phenyl)-3-oxo-heptanoic acid tert-butyl ester 
• 152401-16-6 [4-((3aR,5R,6S,6aR)-6-Benzyloxy-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-ylmethyl)-2,6-dimethoxy-phenoxy]-tert-butyl-dimethyl-silane 

Relevant academic research and scientific papers

Leveraging Open Science Drug Development for PET: Preliminary Neuroimaging of 11C-Labeled ALK2 Inhibitors

Mutations in the gene encoding activin receptor-like kinase 2 (ALK2) are implicated in the pathophysiology of a pediatric brainstem cancer, diffuse intrinsic pontine glioma (DIPG). Inhibitors of ALK2 that cross the blood-brain barrier have been proposed a

Total Synthesis of (±)-Codonopiloneolignanin A

An intramolecular formal [3 + 2] cationic cycloaddition between benzylic carbocation and styrene was developed for the total synthesis of codonopiloneolignanin A. Further study shows benzocycloheptene as a good substrate for 1,3-dipolar cycloaddition, and a model study toward cephalocyclidine A skeleton was reported.

The Palladium-Mediated Cross Coupling of Bromotropolones with Organostannanes or Arylboronic Acids: Applications to the Synthesis of Natural Products and Natural Product Analogues

The bromotropolones (4), (5) and (10) undergo palladium-mediated cross coupling with a wide range of organostannanes to produce alkenyl-, alkyl- and aryl-substituted tropolones.The methodology has been applied to the synthesis of the monoterpenes β-dolabrin (11), β-thujaplicin (12), 4-isopropyl-7-methoxytropolone (13) and β-thujaplicinol (14).Cross coupling of bromotropolones (4), (5) and (10) with various aryltrimethylstannanes or arylboronic acids has permitted the preparation of the bicyclic colchicine analogues (30)-(43) which have been tested for tubulin-binding activity.The X-ray crystal structure of the most active of these systems, compound (38), is reported.