152402-97-6

Basic information

• Product Name: 4-Chloro-2-(chloromethyl)-3-Methyl Pyridine Hydrochloride
• Synonyms: 4-Chloro-2-(chloromethyl)-3-Methyl Pyridine Hydrochloride
• CAS NO: 152402-97-6
• Molecular Formula: C7H8Cl3N
• Molecular Weight: 212.50412
• Mol File: 152402-97-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 242.2°C at 760 mmHg
• Flash Point: 123.6°C
• Appearance: /
• Vapor Pressure: 0.0536mmHg at 25°C
• CAS DataBase Reference: 4-Chloro-2-(chloromethyl)-3-Methyl Pyridine Hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloro-2-(chloromethyl)-3-Methyl Pyridine Hydrochloride(152402-97-6)
• EPA Substance Registry System: 4-Chloro-2-(chloromethyl)-3-Methyl Pyridine Hydrochloride(152402-97-6)

Safety Data

• Hazardous Substances Data: 152402-97-6(Hazardous Substances Data)

Usage

General Description

4-Chloro-2-(chloromethyl)-3-Methyl Pyridine Hydrochloride is a chemical compound with the molecular formula C7H8Cl2N. It is a white to off-white crystalline solid that is soluble in water and organic solvents. 4-Chloro-2-(chloromethyl)-3-Methyl Pyridine Hydrochloride is used in the synthesis of pharmaceuticals and agrochemicals. It is also used as a reagent in chemical reactions. 4-Chloro-2-(chloromethyl)-3-Methyl Pyridine Hydrochloride is a potential irritant and should be handled with care. Its precise properties and applications make it a valuable component in various industrial processes.

InChI:InChI=1/C7H7Cl2N.ClH/c1-5-6(9)2-3-10-7(5)4-8;/h2-3H,4H2,1H3;1H

Upstream product

• 59886-90-7 4-chloro-2,3-dimethylpyridine-N-oxide 
• 37699-43-7 2,3-dimethyl-4-nitropyridine N-oxide 
• 59886-84-9 (4-chloro-3-methylpyridin-2-yl)methyl acetate 
• 59886-85-0 2-hydroxymethyl-4-chloro-3-methylpyridine 

Downstream Products

• 924663-37-6 2-[(4-(3-methoxypropoxy)-3-methyl-pyridin-2-yl-1-oxide)methylsulfonyl]-1H-benzoimidazole 
• 117977-21-6 rabeprazole sulfide 
• 117976-47-3 LY 307640 sulfone 
• 168167-42-8 2-[(RS)-[(4-chloro-3-methylpyridin-2-yl)methyl]sulfinyl]-1H-benzimidazole 
• 103312-62-5 2-[(4-chloro-3-methylpyridin-2-yl)methylsulfanyl]-1H-benzoimidazole 

Relevant articles and documents

Identification and synthesis of potential impurities of rabeprazole sodium

Rabeprazole sodium (1, Achiphex) is a gastric proton pump inhibitor. It causes dose-dependent inhibition of acid secretion and is useful as an anti-ulcer agent. In the process for the preparation of 1, two potential unknown impurities were identified in HPLC at levels ranging from 0.05-0.8%. Based on mass spectral data vide LC-MS, the two impurities were characterized as 2-{[(4-chloro-3-methyl-2-pyridinyl) methyl] sulfinyl}-1H-bezimidazole (2, chloro analogue of rabeprazole) and 2-[{(4-methoxy-3-methyl-2-pyridinyl)methyl} sulfinyl]-1H-benzimidazole (3, methoxy analogue of rabeprazole). The structures were unambiguously established by independently synthesizing them and co-injecting in HPLC. To our knowledge, the compounds 2 and 3 have not been reported as process impurities elsewhere.