152434-75-8 Usage
Molecular Weight
211.14 g/mol
Structure
A derivative of 1,2-benzenediol with fluorine atoms substituted at the 3 and 5 positions, and an amino and hydroxyethyl group at the 4 position.
Appearance
Not specified in the material provided, but likely a solid or crystalline substance.
Applications
Potential applications in pharmaceuticals and medicinal chemistry due to its unique molecular structure and potential biological activity.
Hazards and Risks
Important to handle and use with caution, as it may have potential hazards and risks associated with its handling and use.
Chemical Family
Aromatic diols, specifically a fluorinated derivative of 1,2-benzenediol.
Functional Groups
Contains hydroxyl (-OH), amino (-NH2), and fluorine (-F) functional groups.
Solubility
Not specified in the material provided, but likely soluble in polar solvents such as water or alcohols due to the presence of hydroxyl and amino groups.
Stability
Not specified in the material provided, but may be sensitive to heat, light, or moisture due to the presence of hydroxyl and amino groups.
Reactivity
Not specified in the material provided, but may react with strong acids, strong bases, or oxidizing agents due to the presence of hydroxyl and amino groups.
Check Digit Verification of cas no
The CAS Registry Mumber 152434-75-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,2,4,3 and 4 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 152434-75:
(8*1)+(7*5)+(6*2)+(5*4)+(4*3)+(3*4)+(2*7)+(1*5)=118
118 % 10 = 8
So 152434-75-8 is a valid CAS Registry Number.
152434-75-8Relevant academic research and scientific papers
Chen, George T.,King, Michael,Gusovsky, Fabian,Creveling, Cyrus R.,Daly, John W.,et al.
, p. 3947 - 3955 (1993)
Synthetic routes to difluorinated analogs of the adrenergic agonists, norepinephrine (NE), epinephrine (E), and phenylephrine (PE) have been developed.The syntheses were based on elaboration of the ethanolamine side chains from the appropriately polyfunctionalized benzaldehydes.The benzaldehydes were prepared from precursor difluorinated benzenes by sequential regioselective lithiations and reaction with electrophiles to introduce hydroxyl and carboxaldehyde functionalities.Binding and functional assay data demonstrate that the 2,6-difluorinated analogs are relatively inactive at both α- and β-adrenergic receptors.These results are consistent with earlier observations that 2-fluoro substitution of adrenergic agonists decreases α-adrenergic activity whereas 6-fluoro substitution decreases β-adrenergic activity.
