152460-07-6Relevant articles and documents
Preparation method of 2-methyl-5-nitrophenyl guanidine
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Paragraph 0041-0043, (2021/11/14)
The invention relates to a preparation method of 2-methyl-5-nitrophenyl guanidine, and belongs to the technical field of synthesis of drug intermediates. In order to solve the problems of high reaction corrosivity and low yield in the prior art, the invention provides a preparation method of 2-methyl-5-nitrophenyl guanidine, which comprises the following step: in the presence of an acid-binding agent, carrying out a condensation reaction on 2-chloro-4-nitrotoluene and guanidine hydrochloride in an alcohol solvent to obtain the corresponding product 2-methyl-5-nitrophenyl guanidine. According to the method, high efficiency and conversion rate can be achieved, the product yield reaches 90% or above, and the purity reaches 99% or above. The reaction conditions are mild, the operation is easier, the cost is relatively low, and the industrial production is more facilitated.
COMPOSITIONS AND METHODS FOR INHIBITING KINASES
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Page/Page column 33-34, (2016/11/14)
The present invention provides compounds for the prevention or treatment of cancer or a bacterial or viral infection. Additionally, the present invention provides compositions and methods for using these compounds and compositions in the prevention or treatment of cancer or a bacterial or viral infection in a subject.
PROCESSES FOR THE PREPARATION OF IMATINIB BASE AND INTERMEDIATES THEREOF
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Page/Page column 21, (2013/03/26)
The invention relates to an improved process for the preparation of highly pure imatinib base (99.99% HPLC purity) of formula (I) and the pharmaceutically acceptable acid addition salts thereof. This invention also relates to processes for the preparation of the intermediates in the synthesis of imatinib base.