152460-08-7

Basic information

• Product Name: (2-Methyl-5-nitrophenyl)guanidine nitrate
• Synonyms: (2-METHYL-5-NITROPHENYL)GUANIDINE NITRATE;N-(2-Methyl-5-nitrophenyl)guanidine nitrate;3-Nitro-6-methylphenylguanidine Nitrate;1-(2-Methyl-5-nitrophenyl)guanidine nitrate;2-Methyl-5-nitrophyl)guanidine nitrate;Imatinib-int C
• CAS NO: 152460-08-7
• Molecular Formula: C8H11N5O5
• Molecular Weight: 257.2
• EINECS: 1533716-785-6
• Product Categories: Amines;Aromatics;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Intermediate of Imatinib
• Mol File: 152460-08-7.mol
• Article Data: 26

Chemical Properties

• Melting Point: 218-219 °C
• Boiling Point: 426.7 °C at 760 mmHg
• Flash Point: 211.9 °C
• Appearance: Off-white solid
• Vapor Pressure: 1.73E-07mmHg at 25°C
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: Water
• CAS DataBase Reference: (2-Methyl-5-nitrophenyl)guanidine nitrate(CAS DataBase Reference)
• NIST Chemistry Reference: (2-Methyl-5-nitrophenyl)guanidine nitrate(152460-08-7)
• EPA Substance Registry System: (2-Methyl-5-nitrophenyl)guanidine nitrate(152460-08-7)

Safety Data

• Hazardous Substances Data: 152460-08-7(Hazardous Substances Data)

Usage

Chemical Properties

Off-White Solid

Uses

Different sources of media describe the Uses of 152460-08-7 differently. You can refer to the following data:
1. (2-Methyl-5-nitrophenyl)guanidine nitrate can be used in therapeutic for benign prostatic hyperplasia
2. (2-Methyl-5-nitrophenyl)guanidine nitrate can be used for the preparation of N-(pyridylpyrimidinylaminophenyl) amides as protein kinase inhibitors.

InChI:InChI=1/C8H10N4O2.HNO3/c1-5-2-3-6(12(13)14)4-7(5)11-8(9)10;2-1(3)4/h2-4H,1H3,(H4,9,10,11);(H,2,3,4)

Upstream product

• 420-04-2 CYANAMID 
• 99-55-8 2-methyl-5-nitroaniline 
• 95-53-4 o-toluidine 
• 7697-37-2 nitric acid 

Downstream Products

• 475587-23-6 N-(2-methyl-5-nitrophenyl)-4-(pyridin-2-yl)pyrimidin-2-amine 
• 1079880-48-0 3-(2-fluoro-ethoxy)-4-methanesulfonyl-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide 
• 1079880-99-1 C₂₄H₂₁N₅O₄S 
• 1079880-97-9 C₂₃H₁₈IN₅O₂ 
• 1079880-28-6 N-(3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)-4-methylphenyl)-3(methylsulfonyl)benzamide 
• 1079880-94-6 C₁₇H₁₇N₅ 
• 1008130-08-2 STI-OH 
• 1008130-04-8 SKI₆₉₆ 
• 220127-57-1 imatinib mesylate 
• 1008130-10-6 STLL₃ 

Relevant articles and documents

Synthesis and biological evaluation of phenyl-amino-pyrimidine and indole/oxindole conjugates as potential BCR-ABL inhibitors

Abstract: Indole/isatin conjugated phenyl-amino-pyrimidine derivatives have been synthesized, characterized and evaluated in vitro for their potential as BCR-ABL inhibitors. Among the series, all derivatives (7a–7o) were found to be more cytotoxic than standard Imatinib against K-562 cell line. Compound 7l was the most active in the series with almost two folds more potency than imitanib (IC50 0.65 μM). In vitro enzymatic studies with recombinant ABL kinase enzyme exhibited promising inhibition in the range of 30–71 μM for most of these novel conjugates. In addition, modelling and other computational studies have been carried out to draw insight into the BCR-ABL protein interactions with the target molecules and drug like properties of the conjugates, respectively. [Figure not available: see fulltext.].

Synthesis method of imatinib and imatinib mesylate

The invention relates to a synthesis method of imatinib and imatinib mesylate. The method comprises the following steps: condensing 3-acetylpyridine and N,N-dimethylformamide dimethyl acetal which aretaken as initial raw materials to obtain 3-dimethylamino-1-(3-pyridyl)-2-propen-1-one, then reacting with 2-methyl-5-nitrophenylguanidine nitrate to form a pyrimidine ring, performing nitro reductionto obtain N-(5-amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinamine, amidating the N-(5-amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinamine and 4-(chloromethyl)benzoyl chloride, performing affinitysubstitution with 1-methylpiperazine to obtain imatinib, and salifying the imatinib and methanesulfonic acid. The products obtained by the method have the advantages of few impurities, simplicity in post-treatment, high total yield, greenness, environmental protection and safety, and is suitable for a production process for large-scale industrial production of imatinib mesylate.

2,3-dimethyl-6-urea -2H-indazoles and its preparation method and application

The invention discloses a 2, 3-dimethyl-6-urea-2H-indazole compound shown by the following general formula (I), medicinal salt or a solvent compound thereof, wherein Ar is substituted or unsubstituted phenyl or aromatic matrix. The invention also discloses a preparation method and application of the compound. The compound can regulate signal transduction of tyrosine kinase, inhibit bad cellular proliferation, and particularly has obvious curative effect for tumors.