152467-47-5

Basic information

• Product Name: methyl thieno[3,2-d][1,2,3]thiadiazole-6-carboxylate
• Synonyms: methyl thieno[3,2-d]thiadiazole-6-carboxylate;methyl thieno[3,2-d][1,2,3]thiadiazole-6-carboxylate;Thieno[3,2-d][1,2,3]thiadiazole-6-carboxylic acid, methyl ester
• CAS NO: 152467-47-5
• Molecular Formula: C6H4N2O2S2
• Molecular Weight: 200.24
• Mol File: 152467-47-5.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Solubility: ≤2mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide
• CAS DataBase Reference: methyl thieno[3,2-d][1,2,3]thiadiazole-6-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl thieno[3,2-d][1,2,3]thiadiazole-6-carboxylate(152467-47-5)
• EPA Substance Registry System: methyl thieno[3,2-d][1,2,3]thiadiazole-6-carboxylate(152467-47-5)

Safety Data

• Hazardous Substances Data: 152467-47-5(Hazardous Substances Data)

Usage

Description

Methyl thieno[3,2-d][1,2,3]thiadiazole-6-carboxylate is a chemical compound belonging to the 1,2,3-thiadiazole family, which is known for its diverse applications in various fields, including medicine and agriculture. methyl thieno[3,2-d][1,2,3]thiadiazole-6-carboxylate exhibits properties that make it a promising candidate for use as a bactericide, fungicide, and antiviral agent.

Uses

Used in Pharmaceutical Industry:
Methyl thieno[3,2-d][1,2,3]thiadiazole-6-carboxylate is used as a pharmaceutical agent for its potential applications in medicine. The compound's ability to inhibit and inactivate certain microsomal CYP450 enzymes, such as CYP2E1 and CYP2B4, suggests its potential use in the development of drugs targeting specific enzyme pathways.
Used in Agricultural Industry:
In the agricultural sector, methyl thieno[3,2-d][1,2,3]thiadiazole-6-carboxylate is used as a pesticide, specifically as a bactericide and fungicide. Its antiviral properties also make it a candidate for use in controlling viral infections in crops.
Used in Drug Development:
Methyl thieno[3,2-d][1,2,3]thiadiazole-6-carboxylate is used as a key component in the development of new drugs. Its mechanism-based inactivation of specific CYP450 enzymes indicates its potential role in designing drugs that can modulate enzyme activity, thereby affecting various biological processes.
Overall, methyl thieno[3,2-d][1,2,3]thiadiazole-6-carboxylate is a versatile compound with potential applications in various industries, particularly in the development of pharmaceuticals and agricultural products. Its ability to target specific enzymes and exhibit antiviral properties makes it a promising candidate for further research and development.

in vitro

as a 1,2,3-thiadiazole analog, 2,3-dihydrothieno-thiadiazole carboxylate could both inhibit and inactivate certain microsomal cyp450 enzymes (cyp2e1 and cyp2b4) at 100 μm, but not others (cyp1a2). moreover, p450 2e1 was significantly more sensitive than p450 2b4 to mechanism-based inactivation by 2,3-dihydrothieno-thiadiazole carboxylate when compared by the difference in partition numbers and inactivation rate constants. inactivation rate constants (kinact) determined from plots of 1/kobs versus 1/[i] were 0.08 for 2e1 and 0.04 min-1 for p450 2b4, with kis of 0.1 and 2.0 mm, respectively. the difference in the oxidation of the monocyclic and bicyclic thaidiazoles might account for the ability of 2,3-dihydrothieno-thiadiazole carboxylate to function as a mechanism-based inactivator [1].