15249-89-5Relevant academic research and scientific papers
Water-Soluble Calixarenes as New Inverse Phase-Transfer Catalysts. Their Scope in Aqueous Biphasic Alkylations and Mechanistic Implications
Shoichi, Shimizu,Suzuki, Takashi,Shirakawa, Seiji,Sasaki, Yasuyuki,Hirai, Choichiro
, p. 370 - 378 (2002)
Alkylation reactions of active methylene compounds, alcohols and phenols with alkyl halides in aqueous NaOH solution can be carried out without the need for any added organic solvents in most cases. The water-soluble calix[n]arenes, which contain trimethylammoniomethyl groups on the upper rim, were used as inverse phase-transfer catalysts, resulting in the corresponding alkylated products in good to high yields. The scope of this methodology in aqueous biphasic alkylation reactions and the mechanistic implications are discussed.
Water-soluble calixarenes as new inverse phase-transfer catalysts. Their application to C-alkylations of active methylene compounds in water
Shimizu,Suzuki,Sasaki,Hirai
, p. 1664 - 1666 (2007/10/03)
Alkylation reactions involving active methylene compounds and alkyl halides in aqueous NaOH solution have been developed by using the water-soluble calix[n]arenes (n = 4, 6 and 8) as inverse phase-transfer catalysts, which contains trimethylammoniomethyl groups on the upper rim.
