152507-71-6

Basic information

• Product Name: ALOC-D-PHE-OH DCHA
• Synonyms: ALOC-D-PHENYLALANINE DCHA;ALOC-D-PHE-OH DCHA;ALOC-D-PHE-OH DHCA;ALLYLOXYCARBONYL-D-PHENYLALANINE DICYCLOHEXYL AMMONIUM SALT;ALLOC-D-PHE-OH DCHA;N-ALPHA-ALLYLOXYCARBONYL-D-PHENYLALANINE DICYCLOHEXYLAMIN;N-ALPHA-ALLYLOXYCARBONYL-D-PHENYLALANINE DICYCLOHEXYLAMINE;N-ALPHA-ALLYLOXYCARBONYL-D-PHENYLALANINE DICYCLOHEXYLAMMONIUM SALT
• CAS NO: 152507-71-6
• Molecular Formula: C₁₃H₁₅NO₄
• Molecular Weight: 430.58
• Mol File: 152507-71-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 428.4±45.0 °C(Predicted)
• Appearance: /
• Density: 1.203±0.06 g/cm3(Predicted)
• Storage Temp.: -15°C
• PKA: 3.84±0.10(Predicted)
• CAS DataBase Reference: ALOC-D-PHE-OH DCHA(CAS DataBase Reference)
• NIST Chemistry Reference: ALOC-D-PHE-OH DCHA(152507-71-6)
• EPA Substance Registry System: ALOC-D-PHE-OH DCHA(152507-71-6)

Safety Data

• Hazardous Substances Data: 152507-71-6(Hazardous Substances Data)

Usage

Chemical Properties

White crystalline powder

Upstream product

• 673-06-3 D-(R)-phenylalanine 
• 2937-50-0 Allyl chloroformate 
• 583-47-1 4-benzyl-oxazolidine-2,5-dione 
• 150-30-1 Phenylalanine 
• 394210-47-0 4-benzyl-2,5-dioxo-oxazolidine-3-carboxylic acid allyl ester 
• 115491-93-5 diallyl dicarbonate 

Downstream Products

• 159857-98-4 alloc-D-Phe-OSu 
• 159858-03-4 Carbonic acid 4-{(S)-6-allyloxycarbonylamino-2-[(S)-2-((R)-2-allyloxycarbonylamino-3-phenyl-propionylamino)-3-phenyl-propionylamino]-hexanoylamino}-benzyl ester 4-nitro-phenyl ester 
• 159858-02-3 [(S)-5-[(S)-2-((R)-2-Allyloxycarbonylamino-3-phenyl-propionylamino)-3-phenyl-propionylamino]-5-(4-hydroxymethyl-phenylcarbamoyl)-pentyl]-carbamic acid allyl ester 
• 159858-01-2 (S)-6-Allyloxycarbonylamino-2-[(S)-2-((R)-2-allyloxycarbonylamino-3-phenyl-propionylamino)-3-phenyl-propionylamino]-hexanoic acid 
• 159858-00-1 alloc-D-Phe-Phe-Su 
• 159857-99-5 alloc-D-Phe-Phe 
• 673-06-3 D-(R)-phenylalanine 

Relevant articles and documents

Total Synthesis of Cyclic Lipodepsipeptide Ophiotine

The first total synthesis of the natural nematicidal cyclic lipodepsipeptide ophiotine via a convergent strategy that involved both solid-phase peptide synthesis and liquid phase chemistry is reported. The pre-made dipeptide building block was synthesized

Isolation, Structure Elucidation, Biosynthesis, and Synthesis of Antalid, a Secondary Metabolite from Polyangium species

The isolation, structure elucidation, and synthesis of antalid (1), a novel secondary metabolite from Polyangium sp., is described herein. The structure elucidation of 1 was performed with the aid of mass spectrometry, high field NMR experiments, and crystal structure analysis. The absolute configuration of antalid was confirmed through the Mosher ester method and ultimately by total synthesis. In addition, the biosynthetic origin of this hybrid PKS-NRPS natural product was unraveled by the in silico analysis of its biosynthetic gene cluster.

Cathepsin B-sensitive dipeptide prodrugs. 1. A model study of structural requirements for efficient release of doxorubicin

A series of lysosomal protease-sensitive peptides attached to doxorubicin (DOX) was prepared as model substrates for internalizing anticancer immunoconjugates and potential antimetastasis prodrugs. Rates of cathepsin B-mediated release of free drug was measured for each, and human plasma stabilities for representative examples.