15251-02-2Relevant academic research and scientific papers
SYNTHESIS OF Δ6-, Δ1,6-, AND Δ1,6,16-PROGESTERONE
Kogan, N. A.,Raskin, L. M.,Vlasova, M.I.,Kul'bitskaya, S. M.
, p. 883 - 884 (2007/10/02)
The reaction of bromine and progesterone in a molar ratio of 2:1 leads to the formation mainly of 2,6-dibromoprogesterone, while reaction in a ratio of 3:1 gives 2,6,16-tribromoprogesterone.Their dehydrobromination in boiling lutidine leads to Δ1,6- and Δ1,6,16-progesterone.The dehydrogenation of progesterone by chloranil in tert-butyl alcohol gives Δ6-progesterone with a yield of 48percent.
