15251-04-4Relevant academic research and scientific papers
Further syntheses of cyproterone acetate
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Page/Page column 18, (2010/02/07)
The present invention relates to improved methods for synthesising cyproterone acetate (17α-Acetoxy-6-chloro-1α, 2α-methylene-4,6-pregnadiene-3,20-dione) from solasodine. The methods of the invention are shorter as those of the prior art and therefore more economic.
Bromination of steroidal 3-keto-4,6-diene
Jaime,Reyes,Ruiz,Velez,Mendez,Suarez
, p. 442 - 443 (2007/10/03)
The bromination reaction on 3-keto-4,6-diene steroids, via an epoxide intermediate, with hydrobromic acid in acetic acid medium gives the corresponding 6-bromo derivative. On the other hand, bromination with molecular bromine and subsequent dehydrobromination in an aprotic solvent and basic media afforded the unexpected 4-bromo derivative. In this work we suggest an alternative mechanism for explaining the bromine transposition from C6 to C4.
Synthesis of Steroidal Azides. Part 3. Addition of Halogen Azides to Δ6-Steroids
Carlon, F. Emilie,Draper, Richard W.
, p. 2793 - 2799 (2007/10/02)
The reaction between halogen azides and Δ6-steroids has been investigated.The addition of bromine azide to 3,20-dioxopregna-4,6-dien-17α-yl acetate (5), for example, is shown to give 7α-azido-6β-bromo-3,20-dioxopregn-4-en-17α-yl acetate (10), w
