152559-46-1

Basic information

• Product Name: Benzenepropanoic acid, α-bromo-4-chloro-β-oxo-, ethyl ester
• Synonyms: Benzenepropanoic acid, α-bromo-4-chloro-β-oxo-, ethyl ester;A-BROMO-4-CHLORO-B-OXO-BENZENEPROPANOIC ACID ETHYL ESTER;ETHYL 2-BROMO-3-(4-CHLOROPHENYL)-3-OXOPROPANOATE
• CAS NO: 152559-46-1
• Molecular Formula: C₁₁H₁₀BrClO₃
• Molecular Weight: 305.5523
• Mol File: 152559-46-1.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 343.9±27.0 °C(Predicted)
• Appearance: /
• Density: 1.531±0.06 g/cm3(Predicted)
• PKA: 6.80±0.27(Predicted)
• CAS DataBase Reference: Benzenepropanoic acid, α-bromo-4-chloro-β-oxo-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenepropanoic acid, α-bromo-4-chloro-β-oxo-, ethyl ester(152559-46-1)
• EPA Substance Registry System: Benzenepropanoic acid, α-bromo-4-chloro-β-oxo-, ethyl ester(152559-46-1)

Safety Data

• Hazardous Substances Data: 152559-46-1(Hazardous Substances Data)

Upstream product

• 99-91-2 para-chloroacetophenone 
• 2881-63-2 ethyl (4-chlorobenzoyl)acetate 

Downstream Products

• 91182-98-8 4-chloro-N-(pyrazin-2-yl)benzamide 
• 193979-40-7 6-Chloro-2-(4-chloro-phenyl)-imidazo[1,2-a]pyridine-3-carboxylic acid ethyl ester 
• 39826-33-0 3-[2,4-bis-(4-chloro-phenyl)-thiazol-5-yl]-propionic acid 
• 1027885-86-4 3-(4-Chloro-phenyl)-5-isopropyl-benzofuran-2-carboxylic acid ethyl ester 

Relevant articles and documents

Highly efficient and green synthesis of 2,4-diphenyl substituted thiazoles

2,4-Diphenyl thiazole is an important organic intermediate and its derivatives contain multiple biological properties. In the present study, we reported a new protocol to synthesize 2,4-diphenyl thiazole analogs, which involved the bromination of ethyl benzoylacetates with NBS in the presence of 2-hydroxypropyl-β-cyclodextrin, followed by a direct cyclization with thiobenzamides in water. Compared with the reported method, the current protocol contains less reaction steps, milder reaction conditions, and simpler workup procedure.

Synthesis and biological evaluation of pyrazolylthiazole carboxylic acids as potent anti-inflammatory-antimicrobial agents

Current Letter presents design, synthesis and biological evaluation of a novel series of pyrazolylthiazole carboxylates 1a-1p and corresponding acid derivatives 2a-2p. All 32 novel compounds were tested for their in vivo anti-inflammatory activity by carrageenan-induced rat paw edema method as well as for in vitro antimicrobial activity. All the tested compounds exhibited excellent AI activity profile. Three compounds 1p (R = Cl, R1 = Cl), 2c (R = H, R1 = F) and 2n (R = Cl, R1 = OCH3) were identified as potent anti-inflammatory agents exhibiting edema inhibition of 93.06-89.59which is comparable to the reference drug indomethacin (91.32%) after 3 h of carrageenan injection while most of the other compounds displayed inhibition ≥80%. In addition, pyrazolylthiazole carboxylic acids (2a-2p) also showed good antimicrobial profile. Compound 2h (R = OCH3, R1 = Cl) showed excellent antimicrobial activity (MIC 6.25 μg/mL) against both Gram positive bacteria comparable with the reference drug ciprofloxacin (MIC 6.25 μg/mL).

NOVEL JNK INHIBITORS

Disclosed are substituted imidazo[1,2-a]pyridines, imidazo[1,2-a]pyrazines, imidazo[1,2-c]pyrimidines and imidazo[1,2-d]triazines compounds of the formula: (1.0) Also disclosed are methods for treating JNK1 and ERK mediated diseases using the compounds of formula 1.0.