152564-71-1

Basic information

• Product Name: Bhmd-8HPAD
• Synonyms: Bhmd-8HPAD;1,7-bis(hydroxymethyl)-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydro-2,6-phenanthrenediol
• CAS NO: 152564-71-1
• Molecular Formula: C18H26 O4
• Molecular Weight: 306.4
• Mol File: 152564-71-1.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 500.7°Cat760mmHg
• Flash Point: 233.8°C
• Appearance: /
• Density: 1.229g/cm³
• Vapor Pressure: 7.61E-11mmHg at 25°C
• Refractive Index: 1.597
• CAS DataBase Reference: Bhmd-8HPAD(CAS DataBase Reference)
• NIST Chemistry Reference: Bhmd-8HPAD(152564-71-1)
• EPA Substance Registry System: Bhmd-8HPAD(152564-71-1)

Safety Data

• Hazardous Substances Data: 152564-71-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C18H26O4/c1-17-6-5-16(22)18(2,10-20)15(17)4-3-11-7-12(9-19)14(21)8-13(11)17/h7-8,15-16,19-22H,3-6,9-10H2,1-2H3/t15-,16-,17-,18+/m1/s1

Upstream product

• 136087-63-3 1,4a-dimethyl-6-methoxy-4,4a,9,10-tetrahydro-2(3H)-phenanthrenone 
• 152694-64-9 (1R,4aR,10aS)-1,4a-dimethyl-6-methoxy-1,4,4a,9,10,10a-hexahydro-2-oxophenanthrene-1-carboxylic acid methyl ester 
• 152694-62-7 (R)-(-)-2,3,4,4a,9,10-hexahydro-6-methoxy-1,4a-dimethyl-2-oxophenanthrene 
• 1206-44-6 1,2-Dihydroxy-7-methoxy-1-methyl-tetralin 
• 30021-91-1 6-methoxy-4-methyl-1,2-dihydronaphthalene 
• 6836-19-7 7-Methoxy-1-tetralone 
• 1204-23-5 1-methyl-7-methoxy-2-tetralone 
• 152694-65-0 (1R,4aR,10aS)-1,4a-dimethyl-7-formyl-6-methoxy-1,4,4a,9,10,10a-hexahydro-2-oxophenanthrene-1-carboxylic acid methyl ester 
• 152694-63-8 (1S,4aS,10aR)-1,4a-dimethyl-6-methoxy-1,4,4a,9,10,10a-hexahydro-2-oxophenanthrene-1-carboxylic acid methyl ester 
• 35011-71-3 (S)-(+)-2,3,4,4a,9,10-hexahydro-6-methoxy-1,4a-dimethyl-2-oxophenanthrene 
• 152982-09-7 (1S,4aS,10aR)-1,4a-dimethyl-7-formyl-6-methoxy-1,4,4a,9,10,10a-hexahydro-2-oxophenanthrene-1-carboxylic acid methyl ester 

Relevant articles and documents

Isosteres of the DNA polymerase inhibitor aphidicolin as potential antiviral agents against human herpes viruses

A variety of isosteres of the DNA polymerase inhibitor aphidicolin were synthesized as potential antiherpes agents. Modeling studies indicated that the bicyclooctane C, D rings of aphidicolin could be replaced by an aromatic moiety while maintaining the spatial arrangement of the hydroxyl group equivalent to the essential C18 hydroxyl group of aphidicolin. Of the racemic isosteres synthesized only 13, the compound with the greatest structural similarity to aphidicolin, showed any significant antiviral activity in primary assays. An enantioselective synthesis of the compound was carried out and the 4aS isomer 36 was shown to account for the observed antiviral activity noted against herpes simplex virus 1 and human cytomegalovirus.