152601-85-9

Upstream product

• 104766-16-7 5'-O-(4,4'-dimethoxytrityl)-α-thymidine 
• 4449-43-8 α-deoxythymidine 
• 152581-54-9 5'-O-dimethoxytrityl-3'-O-(tert-butyldimethylsilyl)-α-thymidine 
• 152581-55-0 5'-O-dimethoxytrityl-3'-O-(tert-butyldimethylsilyl)-5-methyl-2'-deoxy-α-cytidine 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 219706-26-0 1-<3'-O-acetyl-2-deoxy-5-O-(4,4'-dimethoxytrityl)-α-D-pentofuranosyl>-5-methyl-4-(1,2,4-triazolyl)pyrimidine-2(1H)-one 
• 219706-37-3 3'-O-acetyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-5-methyl-α-cytidine 
• 219706-25-9 3'-O-acetyl-5'-O-(4,4'-dimethoxytrityl)-α-thymidine 
• 219706-39-5 3'-O-acetyl-N⁴-benzoyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-5-methyl-α-cytidine 
• 156056-16-5 5'-O-dimethyoxytrityl-3'-O-(tert-butyldimethylsilyl)-N-4-benzoyl-5-methyl-2'-deoxy-α-cytidine 

Relevant academic research and scientific papers

Improved targeting of the flanks of a DNA stem using α- oligodeoxynucleotides.-The enhanced effect of an intercalator

2'-Deoxy-5'-O-(4,4'-dimethoxytrityl)-5-methyl-N4-(1-pyrenylmethyl)-α- cytidine (5) was prepared by reaction of 1-pyrenylmethylamine with an appropriate protected 4-(1,2,4-triazolyl)-α-thymidine derivative 3 which was synthesized from 5-O-DMT protected α-thymidine 1. Aminolysis of 3 afforded 3'-O-acetyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-5-methyl-α-cytidine (8). Benzoylation of 8 and removal of acetyl afforded N4-benzoyl-2-deoxy-5-O- (4,4'-dimethoxytrityl)-5-methyl-α-cytidine (10). The amidites of compounds 5 and 10 were prepared and used in α-oligonucleotide synthesis. DNA three-way junction (TWJ) is stabilized when an α-ODN is used for targeting the dangling flanks of the stem in a DNA hairpin. Further stabilization of the TWJ is observed when 5 is inserted into the α-ODN at the junction region.

Oligo-α-deoxyribonucleotides with a modified nucleic base and covalently linked to reactive agents

Solid-phase preparation of oligo-α-deoxyribonucleotides attached to intercalator, chemically or photochemically reactive groups through either their 5′- or 3′-ends, including use of the 5-methyl-α-deoxycytidine.