152602-69-2Relevant academic research and scientific papers
Selective Acylations of 3(5)-Alkyl-5(3)-amino-1H-pyrazoles and a New Pyrazolo-1,2,4-triazole Synthesis
Kirschke, Klaus,Wolff, Erich,Ramm, Matthias,Lutze, Gerhard,Schulz, Burkhard
, p. 1037 - 1042 (2007/10/02)
(Z)-5-Amino-1--1H-pyrazoles 3 have been synthesized by acylation of 3(5)-alkyl-5(3)-amino-1H-pyrazoles 1 with nitrile oxides.The tosylation of the hydroxyimino group of 3 to (Z)-5-amino-1--1H-pyrazoles 4 and the subsequent acetylation of the 5-amino group give (E)- and (Z)-5-acetamido-1--1H-pyrazoles 5, which undergo cyclization under basic conditions to pyrazolo-1,2,4-triazoles 6, 7 or 8. - Key Words: Pyrazoles / Pyrazolo-1,2,4-triazoles
