152628-01-8

Basic information

• Product Name: Methyl 4-(butyrylamino)-3-methyl-5-nitrobenzoate
• Synonyms: METHYL-4-(BUTYRYLAMINO)-3-METHYL-5-NITROBENZOATE;3-Methyl-5-nitro-4-[(1-oxobutyl)amino]-benzoic acid methyl ester;Methyl-4-(Butyrylamino)-3-;3-Methyl-4-Butyrylamido-5-NitrylBenzoicAcidMethylEster[TelmisartanIntermediates];4-BUTANAMIDO-3-METHYL-5-NITROBENZOIC ACID;Methyl -4-(butyrylamino)-3-methyl-5-nitrobenzote;3-Methyl-4-butyrylamido-5-nitro benzoic acid methyl ester;4-butanamide-3-methyl-5-nitrobenzene carboxylate acid cas:(intermediate of telmisartan)
• CAS NO: 152628-01-8
• Molecular Formula: C₁₃H₁₆N₂O₅
• Molecular Weight: 280.28
• EINECS: 1806241-263-5
• Product Categories: INTERMEDIATESOF;(intermediate of telmisartan);pharmaceutical intermediates
• Mol File: 152628-01-8.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 468.052 °C at 760 mmHg
• Flash Point: 236.87 °C
• Appearance: An off-white to Cream-colored powder
• Density: 1.265
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.572
• Storage Temp.: 2-8°C
• PKA: 13.27±0.70(Predicted)
• CAS DataBase Reference: Methyl 4-(butyrylamino)-3-methyl-5-nitrobenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 4-(butyrylamino)-3-methyl-5-nitrobenzoate(152628-01-8)
• EPA Substance Registry System: Methyl 4-(butyrylamino)-3-methyl-5-nitrobenzoate(152628-01-8)

Safety Data

• Hazardous Substances Data: 152628-01-8(Hazardous Substances Data)

Usage

Chemical Properties

white powder

InChI:InChI=1/C13H16N2O5/c1-4-5-11(16)14-12-8(2)6-9(13(17)20-3)7-10(12)15(18)19/h6-7H,4-5H2,1-3H3,(H,14,16)

Upstream product

• 301533-59-5 methyl 4-(n-butyrylamino)-3-methylbenzoate 
• 18595-14-7 methyl 4-amino-3-methylbenzoate 
• 3113-71-1 3-methyl-4-nitrobenzoic acid 
• 24078-21-5 methyl 3-methyl-4-nitrobenzoate 

Downstream Products

• 1098100-91-4 4'-((N,7-dimethyl-N-(2-aminophenyl)-2-propyl-3H-benzo[d]imidazole-5-carboxamide-3-yI)-methyl)-biphenyl-2-nitrile 
• 1098100-88-9 7-methyl-N-(2-methylamino)-phenyl-2-propyl-3-(2'-cyano-4-ylmethylbiphenyl)-3H-benzimidazole-5-carboxamide 
• 1098100-86-7 2-cyano-4'-[2-n-propyl-4-methyl-6-methylcarboxylate-benzimidazole-1-ylmethyl]biphenyl 
• 1098100-87-8 2-cyano-4'-[2-n-propyl-4-methyl-6-carboxylate-benzimidazole-1-ylmethyl]biphenyl 
• 144702-27-2 4'-[[2-n-propyl-4-methyl-6-(1-methyl-benzimidazol-2-yl)-1H-benzimidazol-1-yl]-methyl]-2-cyano-biphenyl 
• 144702-26-1 tert-butyl 4'-[[2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)-benzimidazol-1-yl]-methyl]-biphenyl-2-carboxylate 

Relevant articles and documents

Preparation method of 7-phenyl-6-heptynoic acid

The invention relates to the field of organic chemistry, in particular to a preparation method of 7-phenyl-6-heptynoic acid. The invention provides a preparation method of 7-phenyl-6-heptynoic acid. The preparation method comprises the following steps: carrying out an alkylation reaction on phenyl acetylene and 5-halogenated valeronitrile in the presence of alkali to prepare a compound shown as aformula I; and hydrolyzing the compound shown as the formula I to prepare 7-phenyl-6-heptynoic acid. The provided preparation method of 7-phenyl-6-heptynoic acid has the advantages that raw materialsand auxiliary materials are cheap and easily available, the cost is low; the reaction conditions are mild, the reaction steps are few, the reaction is stable and controllable, especially the cyano hydrolysis reaction and active sites are few, the side reaction happens difficultly, the product can be obtained by adjusting the pH after the reaction is finished, the post-treatment is very simple andconvenient, the yield and quality of the whole route are good, the energy is saved, and the preparation method is environment-friendly.

Design, Synthesis, and Biological Evaluation of 6-Benzoxazole Benzimidazole Derivatives with Antihypertension Activities

A series of new angiotensin II receptor 1 antagonists were prepared. They displayed nanomolar affinity to AT1 receptor and could decrease blood pressure efficiently in spontaneously hypertensive rats. Among them, compounds 1b and 2b could reduce the blood pressure with more or equal potency compared to Losartan. So, compounds 1b and 2b could be considered as potential antihypertension drug candidates.

METHOD FOR NITRATING ANILINE DERIVATIVES

The present invention relates to a process for the highly regioselective aromatic nitration of alkyl 4-alkanoylamino-3-alkyl-benzoates in the 5-position in a mixture containing nitric acid and the use of the resulting products for preparing, in particular, pharmaceutically active benzimidazole derivatives.