152642-35-8 Usage
Description
4-(3,4-DICHLOROPHENYL)-3,4-DIHYDRO-2H-NAPHTHALEN-1-ONE OXIME is an organic compound that serves as an intermediate in the synthesis of the drug metabolite for Sertraline. It is characterized by its pale yellow solid appearance.
Uses
Used in Pharmaceutical Industry:
4-(3,4-DICHLOROPHENYL)-3,4-DIHYDRO-2H-NAPHTHALEN-1-ONE OXIME is used as an intermediate in the synthesis of Sertraline, a widely prescribed antidepressant medication. Its role in the pharmaceutical industry is crucial for the production of this essential drug, which helps in the treatment of various mental health disorders.
Used in Chemical Synthesis:
In the field of chemical synthesis, 4-(3,4-DICHLOROPHENYL)-3,4-DIHYDRO-2H-NAPHTHALEN-1-ONE OXIME is utilized as a key component in the creation of other related compounds. Its unique structure allows for further modification and development of new molecules with potential applications in various industries, including pharmaceuticals, agrochemicals, and materials science.
Check Digit Verification of cas no
The CAS Registry Mumber 152642-35-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,2,6,4 and 2 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 152642-35:
(8*1)+(7*5)+(6*2)+(5*6)+(4*4)+(3*2)+(2*3)+(1*5)=118
118 % 10 = 8
So 152642-35-8 is a valid CAS Registry Number.
152642-35-8Relevant articles and documents
Improved industrial synthesis of antidepressant sertraline
Vukics, Krisztina,Fodor, Tamas,Fischer, Janos,Fellegvari, Iren,Levai, Sandor
, p. 82 - 85 (2002)
(cis-1S)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine hydrochloride, or sertraline hydrochloride, is a very effective antidepressant. This report presents a novel industrial synthesis of sertraline hydrochloride that is in many respects more advantageous than processes reported thus far. N-[4-(3,4-Dichlorophenyl)-3,4-dihydro-1(2H)-naphthalenylidene]-methanamine N-oxide is used as intermediate in our process, which is a stable compound in normal conditions. It can be obtained in a simple reaction from the corresponding tetralone in good yield, using acceptable reagents with regard to environmental and safety respects. Its reduction to the desired cis-racemic amine is stereoselective, and thus it provides sertraline hydrochloride with a purity required for pharmaceutical ingredients.
