1526965-18-3

Upstream product

• 1224157-96-3 (3R,4R,5R)-3,4,5-tris(benzyloxy)-2,3,4,5-tetrahydropyridine 1-oxide 
• 13139-86-1 4-methoxyphenyl magnesium bromide 

Downstream Products

• 1526965-39-8 Ycy₈₈₄ 

Relevant academic research and scientific papers

Novel 2-aryl-3,4,5-trihydroxypiperidines: Synthesis and glycosidase inhibition

Three pairs of novel 2-aryl-3,4,5-trihydroxypiperidines (6-8 and their enantiomers), the piperidine analogues of the pyrrolidine alkaloids radicamine A and radicamine B, were prepared from six-membered cyclic nitrones through a concise two-step procedure, i.e., Grignard reagent addition and deprotection. These novel polyhydroxylated piperidine iminosugars were assayed against 10 types of enzymes. Only compound 8 exhibited weak inhibition (IC50 1080 μmol/L) against β-galactosidase from rat intestinal lactases.