152717-44-7Relevant articles and documents
Total Synthesis of (+/-)-Cembranolide via Cr(II) Mediated Intramolecular Macrocyclization of β-Alkoxycarbonylallyl Halide
Nishitani, Kiyoshi,Konomi, Toshihiko,Mimaki, Youji,Tsunoda, Takashi,Yamakawa, Koji
, p. 1957 - 1960 (2007/10/02)
The ω-formyl-β-methoxycarbonylallyl halide (20), prepared from geraniol and methyl β-hydroxypropionate, was cyclized efficiently and with high stereoselectivity to 14-membered cis-cycloalkenol (21) by CrCl2 in DMF.The cycloalkenol was treated with p-TsOH