152722-90-2Relevant academic research and scientific papers
The 2-Oxoglutarate-Dependent Oxygenase JMJD6 Catalyses Oxidation of Lysine Residues to give 5S-Hydroxylysine Residues
Mantri, Monica,Loik, Nikita D.,Hamed, Refaat B.,Claridge, Timothy D. W.,McCullagh, James S. O.,Schofield, Christopher J.
, p. 531 - 534 (2011)
Amino acid analyses reveal that JMJD6-catalysed hydroxylation of RNA-splicing regulatory protein fragments occurs to give hydroxylysine products with 5S stereochemistry. This contrasts with collagen lysyl hydroxylases, which give 5R-hydroxylated products. The work suggests that more than one subfamily of lysyl hydroxylases has evolved and illustrates the importance of stereochemical assignments in proteomic analyses.
