1527481-41-9Relevant academic research and scientific papers
Synthesis of new mixed phenol/heterocyclic derivatives and studies of their activity as inhibitors of Bax/Bcl-xL interaction
Vo, Duc Duy,Gautier, Fabien,Barillé-Nion, Sophie,Juin, Philippe,Levoin, Nicolas,Grée, René
, p. 301 - 311 (2014/01/06)
We describe here the synthesis of a series of new molecules containing phenol and heteroaromatic moieties, compounds, which have been evaluated for their ability to inhibit Bax/Bcl-xL interactions in BRET assays. Among them, a triazole derivative 13, exhibit a very promising activity, being more potent than the reference compounds acylpyrogallol 1 and ABT 737. These preliminary results demonstrate that derivatives of this family can be attractive to develop new molecules with potent anticancer activity.
