152751-57-0 Usage
Originator
Renagel,Chugai Pharmaceutical
Uses
Different sources of media describe the Uses of 152751-57-0 differently. You can refer to the following data:
1. Sevelamer hydrochloride is a noncalcemic phosphate binder for the treatment of hyperphosphatemia in chronic renal failure or patients suffering from chronic kidney disease.
2. Sevelamer hydrochloride is a noncalcemic phosphate binder for the treatment of hyperphosphatemia in chronic renal failure.
3. Sevelamer HCl is used in the treatment of hyperphosphataemia in patients suffering from chronic kidney disease.
Manufacturing Process
Poly(allylamine hydrochloride) (50% w/w, 426 kg) was charged to a 1000 L reactor and water (200 L) was added. Sodium hydroxide solution (32% w/w,
208 kg) was added, followed by 85 L of water. The mixture was stirred for 1 h
and filtered to a 2500 L reactor. The transfer line was rinsed with water (217
kg) and acetonitrile (1300 L) added. The temperature was adjusted to 40°C
and epichlorohydrin (20 kg) added. The mixture was stirred at 40° to 50°C for
1.5 h and then heated to reflux for 16 h. The resulting product slurry may be
isolated and washed in decanter centrifuge.
Brand name
Renagel (Genzyme).
Therapeutic Function
Antihyperphosphatemic
Veterinary Drugs and Treatments
Sevalamer may be useful for treating hyperphosphatemia associated
with chronic renal failure, particularly when oral aluminum
salts are not tolerated.
Check Digit Verification of cas no
The CAS Registry Mumber 152751-57-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,2,7,5 and 1 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 152751-57:
(8*1)+(7*5)+(6*2)+(5*7)+(4*5)+(3*1)+(2*5)+(1*7)=130
130 % 10 = 0
So 152751-57-0 is a valid CAS Registry Number.
InChI:InChI=1/C3H5ClO.C3H7N/c4-1-3-2-5-3;1-2-3-4/h3H,1-2H2;2H,1,3-4H2
