152803-22-0Relevant academic research and scientific papers
Practical Cu-catalyzed amination of functionalized heteroaryl halides
Yeh, Vince S.C.,Wiedeman, Paul E.
, p. 6011 - 6016 (2006)
The amination of a variety of highly functionalized heterocyclic bromides has been accomplished using a CuI/proline catalyst system. The current study significantly expanded the scope of the reaction by using examples relevant to drug discovery programs a
Pyridinecarboxyimidamide compounds and the use thereof
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, (2008/06/13)
Disclosed are pyridinecarboximidamides having a vasodilating effect (hypotensive activity or antianginal activity), and acid adduct salts thereof. STR1 wherein when R1 represents an alkyl, hydroxyalkyl, carboxyl, amino, acylamino, alkylamino, dialkylamino, aralkylamino, alkylsulfonamide, bisalkylsulfonylamino or hydroxyl group, R2 represents a hydrogen atom and R3 represents a nitroxyl, 2-chlorophenyl or phenyl group; and when R1 represents a hydrogen atom, R2 represents an alkyl, hydroxyalkyl, carboxyl, amino, acylamino, alkylamino, dialkylamino, aralkylamino, alkylsulfonamide, bisalkylsulfonylamino or hydroxyl group and R3 represents a nitroxyl, 2-chlorophenyl or phenyl group. There is also disclosed the use of the compounds represented by the formula (I) for antihypertensive or antianginal purpose.
