152810-94-1Relevant articles and documents
Synthesis and antitumor activity of some new 2-chloroethylnitrosoureas
Filippatos,Papadaki-Valiraki,Roussakis,Verbist
, p. 451 - 456 (2007/10/02)
The synthesis of a series of N-(2-chloroethyl)-N'-(9H-xanthen-9-yl)-N-nitrosoureas and N-(2-chloroethyl)-N'-(9H-thioxanthen-9-yl)-N-nitrosoureas is described. The title compounds were evaluated against NSCLCN6 L16 bronchial epidermoid carcinoma in vitro and some of them were found to be active. N-(2-chloroethyl)-N'-(2-methoxy-9H-xanthen-9-yl)-N-nitrosourea (8e) was active against leukemia P388 tumor system in mice.