152813-56-4Relevant articles and documents
Eco-efficient one-pot tandem synthesis of 1-aryl-1H-tetrazol-5-amine by CAN via in situ generated 1-phenylthiourea and heterocumulene
Kondhare, Dasharath D.,Bhadke, Venkat V.,Deshmukh, Sushma S.,Wakhradkar, Mahesh G.,Totawar, Balaji B.
, (2021/07/28)
A simple, cost-effective, environmentally benign, and efficient one-pot tandem approach to the synthesis of pharmaceutically important 1-aryl-1H-tetrazole-5-amines 3a-k and 4a-k has been described. The reaction utilized 1-phenyl thiourea, which was generated in situ from aqueous ammonia and isocyanates 1a-k, for the formation of heterocumenes using sodium azide, triethylamine, and ceric ammonium nitrate (CAN) to obtain various aryl-substituted 1H-tetrazole-5-amines (3a-k) in good to excellent yields.
Benzodiazepine derivatives
-
, (2008/06/13)
Compounds of Formula (I), and salts and prodrugs thereof, wherein said formula, R 1 represents certain optionally substituted alkyl or C 3-7 cycloalkyl; R 2 represents (II) or (III), where m is 0, 1, 2 or 3; R 9 is H or C 1-6 alkyl; R 10 is imidazolyl, triazolyl or tetrazolyl, and R 11 is H, C 1-6 alkyl or halo; R 3 is C 1-6 alkyl, halo or NR 6 R 7 ; R 4 is C 1-7 alkyl, C 3-10 cycloalkyl, C 3-10 cycloalkylC 1-4 alkyl, C 6-10 bicycloalkyl, optionally substituted aryl, or NR 12 R 13 ; R 5 is H or C 1-4 alkyl; n is 0, 1, 2 or 3; which are CCK and/or gastrin antagonists useful in therapy.
