152813-70-2Relevant academic research and scientific papers
Benzodiazepine derivatives
-
, (2008/06/13)
Compounds of Formula (I), and salts and prodrugs thereof, wherein said formula, R 1 represents certain optionally substituted alkyl or C 3-7 cycloalkyl; R 2 represents (II) or (III), where m is 0, 1, 2 or 3; R 9 is H or C 1-6 alkyl; R 10 is imidazolyl, triazolyl or tetrazolyl, and R 11 is H, C 1-6 alkyl or halo; R 3 is C 1-6 alkyl, halo or NR 6 R 7 ; R 4 is C 1-7 alkyl, C 3-10 cycloalkyl, C 3-10 cycloalkylC 1-4 alkyl, C 6-10 bicycloalkyl, optionally substituted aryl, or NR 12 R 13 ; R 5 is H or C 1-4 alkyl; n is 0, 1, 2 or 3; which are CCK and/or gastrin antagonists useful in therapy.
Controlled modification of acidity in cholecystokinin B receptor antagonists: N-(1,4-benzodiazepin-3-yl)-N′-[3-(tetrazol-5-ylamino)phenyl]ureas
Castro, José L.,Ball, Richard G.,Broughton, Howard B.,Russell, Michael G. N.,Rathbone, Denise,Watt, Alan P.,Baker, Raymond,Chapman, Kerry L.,Fletcher, Alan E.,Patel, Smita,Smith, Alison J.,Marshall, George R.,Ryecroft, Wayne,Matassa, Victor G.
, p. 842 - 849 (2007/10/03)
The design, synthesis, and biological activity of a novel series of CCK-B receptor antagonists (1) which incorporate a tetrazol-5-ylamino functionality attached to the phenyl ring of the arylurea moiety of L-365,260 are described. In these compounds, the
