1528459-46-2Relevant academic research and scientific papers
A disulfide intercalator toolbox for the site-directed modification of polypeptides
Wang, Tao,Wu, Yuzhou,Kuan, Seah Ling,Lamla, Markus,Ng, David Y. W.,Arzt, Matthias,Thomas, Jessica,Weil, Tanja,Dumele, Oliver,Mueller, Jan O.,Barner-Kowollik, Christopher
, p. 228 - 238 (2015/02/19)
A disulfide intercalator toolbox was developed for site-specific attachment of a broad variety of functional groups to proteins or peptides under mild, physiological conditions. The peptide hormone somatostatin (SST) served as model compound for intercalation into the available disulfide functionalization schemes starting from the intercalator or the reactive SST precursor before or after bioconjugation. A tetrazole-SST derivative was obtained that undergoes photoinduced cycloaddition in mammalian cells, which was monitored by live-cell imaging.
Bis-sulfide bioconjugates for glutathione triggered tumor responsive drug release
Wang, Tao,Ng, David Y. W.,Wu, Yuzhou,Thomas, Jessica,Tamtran, Thuy,Weil, Tanja
, p. 1116 - 1118 (2014/01/17)
The reaction of bis-sulfone conjugation reagents with disulfide bonds allows the site-specific modification of various peptides and proteins. Herein, we present the intracellular disintegration of bis-sulfide containing somatostatin bioconjugates under co
