15285-61-7 Usage
General Description
1-Chloro-3-(dibutylamino)propan-2-ol, also known as HD-MAP-65, is a chemical compound with the formula C11H24NOCl. It is a chiral molecule that is widely used as a chiral resolving agent and a versatile intermediate in organic synthesis. It is a colorless to pale yellow liquid that is soluble in organic solvents. 1-Chloro-3-(dibutylamino)propan-2-ol is primarily used in the pharmaceutical industry for the production of various chiral drugs and pharmaceutical intermediates. It has also been reported to exhibit antiproliferative activity against cancer cells and has potential for use in anticancer drug development. Moreover, it is an important reagent for the synthesis of chiral chemicals and is commonly used in asymmetric synthesis and catalysis. Overall, 1-Chloro-3-(dibutylamino)propan-2-ol plays a crucial role in the synthesis of chiral compounds and has a wide range of applications in the pharmaceutical and chemical industries.
Check Digit Verification of cas no
The CAS Registry Mumber 15285-61-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,5,2,8 and 5 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 15285-61:
(7*1)+(6*5)+(5*2)+(4*8)+(3*5)+(2*6)+(1*1)=107
107 % 10 = 7
So 15285-61-7 is a valid CAS Registry Number.
InChI:InChI=1/C11H24ClNO/c1-3-5-7-13(8-6-4-2)10-11(14)9-12/h11,14H,3-10H2,1-2H3
15285-61-7Relevant articles and documents
Activation and reactivity of epoxides on solid acid catalysts
Saikia,Satyarthi,Srinivas,Ratnasamy
, p. 148 - 160 (2008/09/18)
The aminolysis of epoxides over novel solid catalysts (Broensted-acidic SBA-15 functionalized with propylsulfonic acid and Lewis-acidic Ti-MCM-41) is reported. The acidic properties of these catalysts were determined by FTIR spectroscopy and temperature-programmed desorption of pyridine and NH3, respectively. The mesoporous solid acids of the present study are reusable and exhibit significantly higher catalytic activities than known catalysts for opening of the oxirane ring with nitrogen (aromatic and aliphatic amines)-containing and oxygen (alcohols)-containing nucleophiles. A range of β-amino alcohols with high regioselectivity and stereoselectivity were synthesized. Adsorption studies as well as the sigmoid shape of the conversion-versus-time plots show that the epoxide and amine compete for adsorption on the acidic sites ({single bond}SO3H or Ti4+) on the catalyst surface. Epoxide adsorption and activation on acid sites are the more critical processes. Catalytic activity decreases with increasing basicity of the amines and/or the alcohol, as well as the dielectric constant of the solvent.