152902-61-9Relevant academic research and scientific papers
Synthesis of 4-Alkylpyrazoles from 3,5-Diaminopyrazoles
Echevarria, Aurea,Elguero, Jose,Yranzo, Gloria I.,Diez-Bara, Enrique,Hoz, Antonio de la,et al.
, p. 2229 - 2232 (2007/10/02)
The possibility of preparing 4-alkylpyrazole from malononitrile (through C-alkyl malononitriles and 3,5-diamino-4-alkylpyrazoles) has been explored.Although some difficulties arise in the double-deamination step, the method has allowed the synthesis of 4-benzyl-and 4-phenyl-pyrazoles.New 3-halogenopyrazoles have also been prepared.The synthesis of 3,5-diamino-4-iodopyrazole is reported.This elusive compound has a 13C NMR spectrum in which an aromatic carbon (C-4) appears at δ 29,53.
