152915-83-8

Basic information

• Product Name: 6-(BENZYLOXY)-2-NAPHTHYLBORONIC ACID
• Synonyms: 6-BENZYLOXYNAPHTHALENE-2-BORONIC ACID;6-(BENZYLOXY)-2-NAPHTHYLBORONIC ACID;AKOS BRN-0518;6-Benzyloxy-2-naphthaleneboronic acid
• CAS NO: 152915-83-8
• Molecular Formula: C₁₇H₁₅BO₃
• Molecular Weight: 278.11
• Mol File: 152915-83-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 510.4 °C at 760 mmHg
• Flash Point: 262.5 °C
• Appearance: /
• Density: 1.24 g/cm³
• Vapor Pressure: 3.06E-11mmHg at 25°C
• Refractive Index: 1.655
• Storage Temp.: Room temperature.
• CAS DataBase Reference: 6-(BENZYLOXY)-2-NAPHTHYLBORONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(BENZYLOXY)-2-NAPHTHYLBORONIC ACID(152915-83-8)
• EPA Substance Registry System: 6-(BENZYLOXY)-2-NAPHTHYLBORONIC ACID(152915-83-8)

Safety Data

• Hazard Codes: Xi:Irritant
• Statements: R36/37/38:Irritating to eyes, respiratory system and skin.
• Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S37/39:Wear suitable g
• Hazardous Substances Data: 152915-83-8(Hazardous Substances Data)

Usage

General Description

6-(Benzyloxy)-2-naphthylboronic acid is a chemical compound known for its applications in organic chemistry, particularly in coupling reactions. It has the chemical formula C20H17BO3 and is commonly used in organic synthesis, pharmaceuticals, and agrochemicals. 6-(BENZYLOXY)-2-NAPHTHYLBORONIC ACID belongs to the family of organoboron compounds, which are notable for their ability to form stable covalent bonds. It is characterized by a benzene ring attached to an oxygen-containing boronic acid molecule, with a naphthyl group on the other side of the boronic molecule.

InChI:InChI=1/C17H15BO3/c19-18(20)16-8-6-15-11-17(9-7-14(15)10-16)21-12-13-4-2-1-3-5-13/h1-11,19-20H,12H2

Upstream product

• 5419-55-6 Triisopropyl borate 
• 2234-45-9 6-benzyloxy-2-bromonaphthalene 
• 100-39-0 benzyl bromide 
• 15231-91-1 6-bromo-naphthalen-2-ol 

Downstream Products

• 244103-66-0 (E)-3-[2-(6-Benzyloxy-naphthalen-2-ylmethyl)-phenyl]-acrylic acid 

Relevant articles and documents

CuCF3: A [18F]trifluoromethylating agent for arylboronic acids and aryl iodides

Positron emission tomography has emerged as the leading method for medical imaging with fluorine-18 as the most widely used radioactive isotope. Here we report a semi-automated method for the preparation of valuable [ 18F]trifluoromethylcopper, as well as its use for the radiosynthesis of [18F]trifluoromethylarenes and heteroarenes. Mild conditions of [18F]trifluoromethylation make this method particularly useful for the radiosynthesis of pharmacologically relevant [18F] trifluoromethylarenes and heteroarenes. 18F Radiochemistry: A semi-automated method for the fast preparation of radiolabelled (trifluoromethyl)copper is reported (see scheme), thus making [ 18F]CuCF3 almost as accessible as [18F]fluoride itself for the preparation of radiolabelled trifluoromethylated probes. It can be used for the preparation of radiolabelled trifluoromethylarenes from arylboronic acids and aryliodides. This methodology is clean, efficient and consistent with the specific requirements of radiochemistry.

Carboxylic acids and acylsulfonamides, compositions containing such compounds and methods of treatment

Compounds of formula I: as well as pharmaceutically acceptable salts, hydrates and esters thereof, are disclosed. The compounds are useful for treating or preventing prostaglandin mediated diseases. Pharmaceutical compositions containing such compounds and methods of treatment are also included.