152917-50-5Relevant articles and documents
Naphthalenic Lignan Lactones as Selective, Nonredox 5-Lipoxygenase Inhibitors. Synthesis and Biological Activity of (Methoxyalkyl)thiazole and Methoxytetrahydropyran Hybrids
Ducharme, Yves,Brideau, Christine,Dube, Daniel,Chan, Chi-Chung,Falgueyret, Jean-Pierre,et al.
, p. 512 - 518 (1994)
Combinations of structural elements found in (methoxyalkyl)thiazole 1a and methoxytetrahydropyran 2a with a naphthalenic lignan lactone produce the potent 5-lipoxygenase (5-LO) inhibitors 3 and 4.While the nature of link Y-Z has a major effect on the in v