152922-73-1

Basic information

• Product Name: Methyl 1-(Mercaptomethyl)cyclopropaneacetate
• Synonyms: METHYL 1-(MERCAPTOMETHYL)CYCLOPROPANE ACETATE;Metyl 1-(Mercaptomethyl)Cyclopropane Acetate;Methy 1-(Mercaptomethyl)cyclopropane acetate;ETHYL [1-(MECAPTOMETHYL)CYCLOPROPYL]ACETATE[FOR MONTELUKAST];CYTAM METHYL 2-[1-(MERCAPTOMETHYL) CYCLOPROPYL] ACETATE;Methyl 2-(1-(MercaptoMethyl)cyclopropyl)acetate;Methyl 2-[1-(sulfanylMethyl)cyclopropyl]acetate;Methyl [1-(mercaptomethyl)cyclopropyl]acetate
• CAS NO: 152922-73-1
• Molecular Formula: C₇H₁₂O₂S
• Molecular Weight: 160.23
• EINECS: 1312995-182-4
• Mol File: 152922-73-1.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 208.899 °C at 760 mmHg
• Flash Point: 92.703 °C
• Appearance: /
• Density: 1.11 g/cm³
• Vapor Pressure: 0.209mmHg at 25°C
• Refractive Index: 1.495
• PKA: 10.41±0.10(Predicted)
• CAS DataBase Reference: Methyl 1-(Mercaptomethyl)cyclopropaneacetate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 1-(Mercaptomethyl)cyclopropaneacetate(152922-73-1)
• EPA Substance Registry System: Methyl 1-(Mercaptomethyl)cyclopropaneacetate(152922-73-1)

Safety Data

• Hazardous Substances Data: 152922-73-1(Hazardous Substances Data)

Usage

General Description

Methyl 1-(Mercaptomethyl)cyclopropaneacetate is a chemical compound with the molecular formula C8H12O3S. It is a cyclopropane derivative with a mercaptomethyl group and an acetate group attached to the cyclopropane ring. Methyl 1-(Mercaptomethyl)cyclopropaneacetate is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is a colorless, clear liquid with a faint odor, and it is stable under normal conditions. Methyl 1-(Mercaptomethyl)cyclopropaneacetate is primarily utilized in organic synthesis and can undergo various chemical reactions to produce a range of important compounds.

InChI:InChI=1/C7H12O2S/c1-9-6(8)4-7(5-10)2-3-7/h10H,2-5H2,1H3

Upstream product

• 67-56-1 methanol 
• 162515-68-6 1-(sulfanylmethyl)cyclopropaneacetic acid 
• 75-11-6 diiodomethane 
• 152922-72-0 1-(Acetylthiomethyl)cyclopropaneacetonitrile 
• 7732-18-5 water 

Downstream Products

• 158966-92-8 montelukast 
• 855473-51-7 1-(((1(R)-(3-(2(E)-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropane acetic acid methyl ester 
• 162515-68-6 1-(sulfanylmethyl)cyclopropaneacetic acid 
• 1187586-61-3 [R, E]-[[1-[3-[2-(7-chloro-2-quinolinyl)-2-(S)-[(carboxymethyl)cyclopropyl]methyl]thio]ethyl]phenyl]-3-[[[[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]-cyclopropane acetic acid 
• 1187586-58-8 [R, E]-[[1-[3-[2-(7-chloro-2-quinolinyl)-2-(R)-[(carboxymethyl)cyclopropyl]methyl]thio]ethyl]phenyl]-3-[[[[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]-cyclopropane acetic acid 
• 1000788-70-4 1-(((1-(R)-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-((1-tetrahydropyranyloxy)-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropyl acetate 

Relevant articles and documents

Synthesis of Cyclopropyl Ester and Amide Substituted Pyrimidinediones as Protoporphyrinogen Oxidase-Inhibiting Herbicides

The protoporphyrinogen oxidase (PPO) enzyme is involved in the biosynthesis of chlorophyll and is an important target in research for development of new herbicides. In this study, new pyrimidinedione compounds with thioester tail group containing cyclopropyl moiety are synthesized from the commercially available 2-(1-(mercaptomethyl)cyclopropyl)acetic acid. The herbicidal activity of the synthesized compounds is also evaluated. Most of the synthesized compounds exhibit herbicidal activities against both monocot and dicot weeds. In particular, 10a showed similar activity to the control material, Saflufenacil. And when against the monocot weeds, Echinochloa crusgalli and Digitaria sanguinalis, 10a shows superior activity to Saflufenacil.

A PROCESS FOR PREPARATION OF MONTELUKAST SODIUM SALT

The present invention relates to a process for the preparation of montelukast sodium salt. The process includes (a) reacting 2-(2-(3-(S)-(3-(7-chloro-2- quinolinyl)-ethenyl) phenyl)-3-hydroxypropyl)- phenyl-2-propanol of Formula (II) with diphenyl chloro phosphate to get a compound of Formula III; (b) condensing the compound of Formula III with a compound of Formula IV to get compound of Formula V; (c) and converting the compound of Formula V to montelukast sodium of Formula (I).

Process for preparation of [1-(mercaptomethyl)cyclopropyl]acetic acid and related derivatives

The present invention provides a novel process for preparing [1-(mercaptomethyl)cyclopropyl]acetic acid with high purity and related derivatives.