152944-68-8Relevant academic research and scientific papers
Synthesis, crystal structure and antiproliferative mechanisms of gallium(iii) complexes with benzoylpyridine thiosemicarbazones
Liu, Taichen,Qi, Jinxu,Wang, Yihong,Zhao, Wei,Zheng, Xinhua
, p. 18553 - 18559 (2020)
We have prepared six thiosemicarbazone ligands and synthesized the corresponding Ga(iii) complexes. The antitumor activity of the ligand increases with its lipophilicity, and the antitumor activity of the Ga(iii) complexes is affected by the ligands. Sinc
Synthesis, X-ray structures and cytotoxic effects of a Cu(II)- and a Zn(II) thiosemicarbazones on human epidermoid carcinoma cell A431
Biswas, Chinmoy,Chatterjee, Arnab,Bhattacharya, Sonali,Mandal, Deba Prasad,Bhattacharjee, Shamee,Ghosh, Rajarshi
, (2021)
Thiosemicarbazone metal complexes [Cu(L)(2-benzpy)]ClO4 (1) and [Zn(L)2] (2) [L = 2-benzoylpyridine-N(4)-methyl-3-thiosemicarbazone), 2-benzpy = 2-benzolylpyridine] were synthesized and X-ray crystallographically characterized. The metal centre in compound 1 has a distorted square planar geometry while in compound 2, the metal centre has a distorted octahedral geometry. Both the molecules induce cytotoxic effects on A431 skin carcinoma cell line in 24 h incubation and significantly enhances hypoploid cell population in cell cycle phase distribution below IC50 dose. Application of both the two molecules exhibit apoptotic induction and genotoxic activity in 24 h exposure. Graphical abstract: [Figure not available: see fulltext.]
Stabilization of CuII-I Bonds Using 2-Benzoylpyridine Thiosemicarbazones - Synthesis, Structure, Spectroscopy, Fluorescence, and Cyclic Voltammetry
Indoria, Shikha,Lobana, Tarlok S.,Singh, Deep,Kumari, Sangita,Kumari, Parveen,Bala, Tanu,Kamal, Ajar,Jassal, Amanpreet K.,García Santos, Isabel,Castineiras, Alfonso,Jasinski, Jerry P.
, p. 5106 - 5117 (2015)
The reactions of copper(I) iodide with N1-substituted 2-benzoylpyridine thiosemicarbazones [(C6H5)(C5H4N)C2=N3-N2H-C(=S)-N1HR (R = Me, HLMe; Et,
Four Cu(II) complexes based on antitumor chelators: Synthesis, structure, DNA binding/damage, HSA interaction and enhanced cytotoxicity
Liu, Ya-Hong,Li, Ang,Shao, Jia,Xie, Cheng-Zhi,Song, Xue-Qing,Bao, Wei-Guo,Xu, Jing-Yuan
, p. 8036 - 8049 (2016)
Four novel copper(ii) complexes [CuII(Bp4mT)(μ-Cl)]2 (1), [CuII(μ-Bp4mT)Br]2 (2), [CuII(HBpT)Cl] (3), and [CuII(HBpT)Br] (4) (Bp4mT = 2-benzoylpyridine-4-methylthiosemicarbazone, HBpT = 2-b
FTO small-molecule inhibitor gold complex and synthesis method thereof
-
Paragraph 0010; 0033-0038, (2020/12/30)
The invention discloses an FTO small molecule inhibitor gold complex and a synthetic method thereof. The synthetic method comprises the steps that 2-benzoylpyridine and thiosemicarbazide are taken, mixed and dissolved in methyl alcohol, concentrated sulfu
Platinum complex taking 2-benzoylpyridine thiosemicarbazone as ligand as well as synthesis method and application of platinum complex
-
Paragraph 0033-0036, (2020/12/31)
The invention discloses a thiosemicarbazone platinum complex taking 2-benzoyl pyridine as a ligand as well as a synthesis method and application of the thiosemicarbazone platinum complex. 2-benzoyl pyridine and thiosemicarbazone are selected for condensat
THIOSEMICARBAZONE COMPOUNDS AND USE THEREOF
-
Page/Page column 19, (2010/04/03)
A method of treating a proliferative disease in a vertebrate, the method comprising administering to the vertebrate a therapeutically effective amount of at least one compound of formula (I) (I) wherein R1 is selected from H, C1-6 alkyl, C2-6 alkenyl and phenyl; R2 is selected from H, C1-6 alkyl, C2-6 alkenyl and phenyl; wherein R1 and R2 are the same or different, or a salt, hydrate, or iron complex thereof, or a pharmaceutical composition comprising said compound, salt, hydrate or iron complex and a pharmaceutically acceptable carrier, diluent or excipient.
