15295-33-7Relevant academic research and scientific papers
On water reaction of deactivated anilines with 4-methoxy-3-buten-2-one, an effective butynone surrogate
Jebari, Meriam,Pasturaud, Karine,Picard, Baptiste,Maddaluno, Jacques,Rezgui, Farhat,Chataigner, Isabelle,Legros, Julien
, p. 11085 - 11087 (2016)
Poorly nucleophilic aromatic amines (nitroanilines, chloroanilines, etc.) react readily and selectively with trans-4-methoxy-3-buten-2-one, a convenient, effective and inexpensive surrogate for 3-butyn-2-one, to afford (Z)-enaminones. The efficiency of the reaction mostly lies in the use of water as a solvent, which enhances the reaction rate by a 45 to 200-fold factor with regard to other media.
A Method for the Preparation of β-Amino-α,β-unsaturated Carbonyl Compounds: Study of Solvent Effect and Mechanism
R. S., Reyno,Sugunan, Akash,S., Ranganayakulu,Suresh, Cherumuttathu H.,Rajendar, Goreti
supporting information, p. 1040 - 1045 (2020/02/15)
An efficient method for the preparation of β-amino-α,β-unsaturated carbonyl compounds is demonstrated. Bench-stable sodium 3-oxo-enolates were prepared from carbonyl compounds, and reacted with amines in the presence of an acid and a desiccant. DFT studie
