15297-64-0Relevant articles and documents
Inhibitor-Induced Dimerization of an Essential Oxidoreductase from African Trypanosomes
Wagner, Annika,Le, Thien Anh,Brennich, Martha,Klein, Philipp,Bader, Nicole,Diehl, Erika,Paszek, Daniel,Weickhmann, A. Katharina,Dirdjaja, Natalie,Krauth-Siegel, R. Luise,Engels, Bernd,Opatz, Till,Schindelin, Hermann,Hellmich, Ute A.
supporting information, p. 3640 - 3644 (2019/02/09)
Trypanosomal and leishmanial infections claim tens of thousands of lives each year. The metabolism of these unicellular eukaryotic parasites differs from the human host and their enzymes thus constitute promising drug targets. Tryparedoxin (Tpx) from Tryp
Indeno[1,2-b]pyrazin-2,3-diones: A new class of antagonists at the glycine site of the NMDA receptor with potent in vivo activity
Jimonet, Patrick,Ribeill, Yves,Bohme, Georg Andrees,Boireau, Alain,Chevé, Michel,Damour, Dominique,Doble, Adam,Genevois-Borella, Arielle,Herman, Frédéric,Imperato, Assunta,Le Guern, Sylvain,Manfré, Franco,Pratt, Jeremy,Randle, John C. R.,Stutzmann, Jean-Marie,Mignani, Serge
, p. 2371 - 2381 (2007/10/03)
Indeno[1,2-b]pyrazin-2,3-diones have been identified as a novel series of potent ligands on the glycine site of the NMDA receptor. To improve their in vivo activities, an acetic acid-type side chain was introduced to the 5- position, giving water-soluble
