1529809-38-8Relevant academic research and scientific papers
Enantiospecific, nickel-catalyzed cross-couplings of allylic pivalates and arylboroxines
Srinivas, Harathi D.,Zhou, Qi,Watson, Mary P.
supporting information, p. 3596 - 3599 (2014/07/21)
We have developed an enantiospecific, nickel-catalyzed cross-coupling of unsymmetric 1,3-disubstituted allylic pivalates with arylboroxines. The success of this reaction relies on the use of BnPPh2 as a supporting ligand for the nickel(0) catalyst and NaOMe as a base. This method shows excellent functional group tolerance and broad scope in both the allylic pivalate and arylboroxine, enabling the preparation of 1,3-diaryl allylic products in high yields with excellent levels of regioselectivity and stereochemical fidelity.
